定量彩色室壁运动技术探讨犬左室舒张功能异常与心肌缺血程度的关系的实验研究  

Experimental Study on Exploring the Relation Between Left Ventricular Diastolic Function Abnormality and Extent of Myocardium Ischemia by Quantitative Color Kinesis

作　　者：姚志勇[1] 张军[1] 李军[1] 田雪[1] 贺建国[1] 苏军芳[1] 孙晖[1] 

机构地区：[1]西安市第四军医大学西京医院超声科,710032

出　　处：《中国超声医学杂志》2002年第6期405-408,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的 :应用定量彩色室壁运动技术 (QCK)探讨左室舒张功能异常与心肌缺血程度的关系及阈值。方法 :13条健康杂种犬 ,分别在正常、血流量减少 5 0 %、 75 %、 95 %四种状态下采集左室乳头肌水平短轴和心尖四腔切面的舒张期彩色室壁运动技术 (CK)的图像 ,用带有 QCK分析软件的计算机对采集到的图像进行分析处理 ,由计算机自动输出舒张期各节段局部面积变化百分率 [RACd (% ) ]和平均充盈时间 (MFT)。结果 :13条犬共获得 14 5(92 .95 % )幅可供分析的左室舒张期 CK图像。正常对照状态下左旋支供血区各节段 RACd为 [(45 .2 6± 16 .4 7) %～ (72 .0 8± 17.2 5 ) % ],MFT为 [(114 .33± 6 .11) ms～ (130 .6 7± 14 .4 6 ) ms]。因定量狭窄冠脉左旋支主干分支下 1cm,狭窄处以下供血区左室乳头肌水平短轴和心尖四腔切面的相对节段数值与正常对照状态作比较 :缺血 5 0 %状态下各节段的 RACd和 MFT分无明显变化 ;缺血 75 %状态下 pst、 1at、b- 1t、m- 1t、a- 1t的 RACd和 MFT分别为 [(2 4 .10± 6 .32 ) %～ (39.71± 13.86 ) % ]和 [(97.33± 3.2 1) ms～ (10 2 .33± 5 .5 1) ms],较正常状态均明显减低 ,差异显著 ,P值 <0 .0 5 ;缺血 95 %状态下 pst、 1at、b- 1t、m- 1t、a- 1t的 RACd和 MFT分别为 [(9.0 8?Objective:To explore the relation between left ventricular diastolic function abnormality and degree of myocardium ischemia and find a liminal value of coronary flow decrease for appearing to left ventricular diastolic function abnormality.Methods:Echocardiographic examinations were performed in 13 dogs whose circumflex branch of coronary artery were constricted.Diastolic color kinesis images were acquired at both SAX and A4C at 4 states,which was normal flow,flow was decreased to 50% of normal flow,flow was decreased to 50% of normal flow,and flow was decreased to 5% of normal flow.These CK images were analyzed by using computer with QCK software.Regional area changes of diastole(RACd)and mean filling time(MFT)were calculated automatically.Results:145 (92 95%)with high quality diastolic CK images that may be analyzed were acquired of 13 dogs.Value of RACd and MFT of the area supplied by circumflex branch of coronary artery in control were from 45 26±16 47% to 72 08±17 25% and from 114 33±6 11ms to 130 67±14 46ms respectively.Because circumflex branch of coronary artery were constricted,we compared value of the area supplied by circumflex branch of coronary artery in stenosis with that in control condition:In flow decreased to 50% of normal flow,there were no significant diference between valve in this state and in control condition.In flow decreased to 75% of normal flow,value of RACd and MFT of pst,lat,b 1t,m 1t and a 1t were from 24 10±6 32% to 39 71±13 86% and from 97 33±3 21 ms to 102 33±5 51ms respectively,which were significantly lower than that of in normal, P <0 05.In flow decreased to 95% of normal flow,value of RACd and MFT of pst,lat,b 1t,m 1t and a 1t were from 9 08±2 96% to 16 11±1 59% and from 85 00±5 60ms to 95 50±5 69ms respectively,which were significantly lower than that of in normal, P <0 01.RACd of a sp,m sp and b sp had the tendency to increase,in which b sp had statistical significance, P <0 01.MFT of a sp,m sp,b sp,inf and sp had t

关 键 词：定量彩色室壁运动技术 左室舒张功能异常 心肌缺血 实验研究 

分 类 号：R445.1[医药卫生—影像医学与核医学]