特立加压素和垂体后叶素对肝硬化大鼠门脉压力及胃粘膜血流量的影响  

Effects of Terlipressin and Pituitrin on Portal Vein Pressure and Gastric Mucosal Blood Flow in Cirrhotic Rats with Portal Hypertension

作　　者：王天才[1] 周峻峰[1] 刘辉[1] 李木蓬[1] 梁扩寰[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肝病研究所,武汉430030

出　　处：《华中科技大学学报（医学版）》2002年第3期256-258,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：卫生部计财司临床重点学科 -内科肝脏病学建设基金资助项目 (No. 0 7- 95 0 10 - 2)

摘　　要：为探讨特立加压素和垂体后叶素对肝硬化大鼠门脉压力、平均动脉压及胃粘膜血流量的影响 ,采用美国BIOPAC公司生产的 MP10 0型多导生理记录仪测定肝硬化大鼠门脉压力和胃粘膜血流量 ,并观察给予特立加压素和垂体后叶素前后门脉压力及胃粘膜血流量的变化。发现特立加压素和垂体后叶素均可显著降低肝硬化大鼠门脉压力及胃粘膜血流量 ,但特立加压素对动脉压力的影响较垂体后叶素小 ,且降低胃粘膜血流量的速度快 ,结果表明特立加压素对于降低肝硬化门脉高压较垂体后叶素为优 。To investigate the effects of terlipressin and pituitrin on portal vein pressure (PVP) and gastric mucosal blood flow in cirrhotic rats with portal hypertension, cirrhotic rat models were made by bile duct ligation (BDL). The PVP, mean artery pressure (MAP) and gastric mucosal blood flow were measured before and after cirrhotic rats were administered with terlipressin or pituitrin respectively. It was found that both terlipressin and pituitrin could obviously reduce the PVP and the gastric mucosal blood flow in cirrhotic rats. But terlipressin has less effect on the mean artery pressure and reduces the gastric mucosal blood flow faster than pituitrin. It was suggested that terlipressin had a satisfactory effect in the treatment of bleeding esophageal varices and portal hypertensive gastropathy.

关 键 词：特立加压素 肝硬化 门脉高压 胃粘膜血流量 

分 类 号：R977.1[医药卫生—药品] R575.2[医药卫生—药学]