肺结核患者纤支镜灌洗液IL-6及IL-8测定的临床意义  

The clinic value of detecting interleukin-6 and interleukin-8 in bronchoalveolar lavage fluids from pulmonary tuberculosis

作　　者：王安平[1] 庞玉瑛[1] 

机构地区：[1]安徽医科大学第一附属医院呼吸内科,合肥230022

出　　处：《安徽医科大学学报》2002年第2期137-138,共2页Acta Universitatis Medicinalis Anhui

摘　　要：目的　探讨肺结核患者纤支镜灌洗液中IL 6、IL 8水平的变化及其与结核病活动的关系。方法　分别对 31例健康志愿者和 31例肺结核患者的病变肺局部进行纤支镜灌洗 ,用ELISA法分别测定其灌洗液中IL 6、IL 8的水平。结果　实验组纤支镜灌洗液中IL 6、IL 8水平高于对照组 (P<0 0 1) ,且其水平与结核活动度呈正相关。结论　肺结核患者病变肺局部存在细胞免疫反应 ,其产生的IL 6及IL 8水平明显增高 ,且影响肺结核的临床表现 ,与结核病活动度呈正相关。Objeetive To explore the changes of interlenkin-6 and interlenkin-8 in bronchoalveolar lavage fluid(BALF) from pulmonary tuberculosis(TB) patients. Methods BALF cells were obtained from group A: 31 normal control volunteers ;group B:31 pulmonary TB patients. IL-6 and IL-8 were determined using Sandwich ELISA. Results In group B, the interlenkin-6 and interlenkin-8 〔(421±101.5) and ( 1 150 ±105.5), respectively〕 were not only significantly higher than those of the group A 〔(25±1.7) and (101±34.3), respectively, all P<0.01〕, but also affected presentation and outcome in pulmonary TB. Conclusions The levels of IL-6 and IL-8 in BALF from pulmonary tuberculosis patients are significantly higher than those of nomal volunteers,and affects presentation and outcome of pulmonary tuberculosis patients .

关 键 词：肺结核 纤支镜 灌洗液 IL-6 IL-8 临床意义 

分 类 号：R521[医药卫生—内科学]