灯盏花素对异丙肾上腺素诱导沙土鼠急性心肌缺血的作用  

Effects of Breviscapin on Isoprenaline-Induced Acute Myocardial Ischemia in Gerbils

作　　者：雷秀玲[1] 李玲[2] 陈植和[2] 吴婉玲[2] 

机构地区：[1]昆明医学院药理教研室 [2]云南省天然药物药理重点实验室,昆明650031

出　　处：《昆明医学院学报》2002年第2期21-23,共3页Journal of Kunming Medical College

基　　金：云南省科委应用基础青年基金资助项目 (96C0 76Q)

摘　　要：采用微量异丙肾上腺素 (ISO)恒速静注造成沙土鼠急性心肌缺血模型 ,观察灯盏花素对沙土鼠急性心肌缺血的影响 ,以心电图ST段降低及ST段降低的总和 (ΣΔST)为指标反映缺血程度 .结果表明 :注射灯盏花素 5 0 ,10 0mg/kg ,对ISO诱导沙土鼠急性心肌缺血有一定的保护作用 .建立的沙土鼠急性心肌缺血模型具有稳定性和重复性好、快捷有效、易掌握、耗费药品少等优点 。An acute myocardial ischemia model in gerbils was made by steadied intravenous injection isoprenaline(ISO).The total flavonoids(beiviscapin) were isolated from erigeron beiviscapus. The effects of beiviscapin on the model were studied. The results showed that beiviscapin at 50?mg/kg and 100?mg/kg inhibited S-T segment's decline (P<0.05) and decreased ∑△ST(P<0.05) at the second minute after steadied iv ISO. It is suggested that beiviscapin can protect against acute ischemia injury during the short periods. This ISO-induced acute myocardial ischemia model on gerbils has some significant advantages, for example, higher stability, good duplication, quickly filtrating, easily mastering. The model may be used for quickly studying and screening the drugs protecting from myocardial ischemia.

关 键 词：灯盏花素 异丙肾上腺素 沙土鼠 急性心肌缺血 

分 类 号：R259.422[医药卫生—中西医结合] R282.71[医药卫生—中医内科学]