调心方对Aβ所致Alzheimer痴呆大鼠线粒体呼吸功能的影响  

The effect of HBR on mitochondrial respiratory function in Aβinduced Alzheimer's disease rats

作　　者：王奕[1] 金国琴[1] 徐维蓉[1] 朱龙英[1] 叶其明[1] 赵伟康[1] 林水淼[1] 

机构地区：[1]上海中医药大学基础医学院,上海200032

出　　处：《中国老年学杂志》2002年第3期206-208,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金重点项目 (C0 30 50 31 1 )

摘　　要：目的　观察调心方对 Aβ所致痴呆大鼠空间学习记忆能力和脑线粒体呼吸功能的影响。方法　大鼠左侧脑室注射 Aβ1 - 4 0活性片段造成大鼠 Aβ沉积型 Alzheimer病 (AD)模型 ,Morris水迷宫法观察大鼠空间学习记忆能力 ;Clark氧电极法测定各组大鼠皮层细胞线粒体呼吸功能和呼吸链氧化酶的活性以及调心方的作用。结果　与正常对照组比较 ,模型鼠空间学习记忆能力、皮层细胞线粒体呼吸功能和呼吸链中氧化酶活性均显著降低 ,调心方对上述指标有不同程度的改善作用。结论　调心方具有改善 AD大鼠空间学习记忆能力。Objective To investigate the effect of Heart Benifitting Recipe (HBR) on spatial learning memory and mitochondrial respiratory function in β AP induced Alzheimer's disease (AD) rats. Methods Injected β AP 1 40 fragments to left lateral ventricle of the SD rats, then AD model was induced by β AP deposited. Observe the spatial learning memory ability with Morris water maze test, The mitochondrial respiratory function was assayed in a Clack oxygen electrode. Results As compared with normal rats, AD rats have a significantly declined in spatial learning memory and mitochondrial respiratory function. Treatment with HBR has improved effects in varying degrees. Conclusions HBR has a protective effect on spatial learning memory and mitochondrial respiratory function in AD rats.

关 键 词：调心方 AΒ ALZHEIMER痴呆 大鼠 线粒体呼吸功能 影响 中药 呼吸链 氧化酶 

分 类 号：R277.791.6[医药卫生—中医学] R289.5