体外反搏对犬血流脉动性和血管阻力的影响  

Effects of External Counterpulsation on the Pulsatility of Blood Pressure and Blood Flow in Dogs

作　　者：刘磊[1] 伍贵富[2,3] 周少春[2] 郑振声[2] 靳亚非[1] 杨世方[2] 詹澄扬[2] 方典秋[2] 钱学贤[1] 

机构地区：[1]第一军医大学珠江医院心内科 [2]中山医科大学辅助循环实验室 [3]中山医科大学附属第一医院心内科,广州510080

出　　处：《生物医学工程学杂志》2002年第2期196-199,共4页Journal of Biomedical Engineering

基　　金：国家"九 .五攻关"(96-90 6-0 2 -12 );中美辅助循环研究基金资助项目 (0 40 )

摘　　要：为了评价体外反搏是否具有扩张血管和增加血流脉动性的作用 ,制造了犬急性心肌梗塞模型 ,并使犬存活 6周。麻醉后 ,测定左侧颈总动脉血流量和右侧颈总动脉血压。计算反搏前和反搏中脉压差、血压脉动指数、血压的标准差、流量差、流量脉动指数、流量标准差和平均血管阻力。结果显示脉压差、血压脉动指数和血压标准差三个血压脉动性指标分别由反搏前的 30± 9mm Hg、1.2 6± 0 .0 5、8.7± 2 .5 mm Hg升高到反搏中的 4 3± 8mm Hg(P<0 .0 5 )、1.5 4± 0 .13、12 .4± 2 .0 mm Hg (P<0 .0 5 )。流量差、流量脉动指数和流量标准差三个血流脉动性指标分别由反搏前的 317± 4 8ml/ min、2 .85± 0 .2 1、96± 2 1ml/ min升高到反搏中的 4 4 7± 88m l/ min、4 .5 6± 0 .90、131±39m l/ m in,P值均于小 0 .0 5。平均血管阻力由反搏前的 5 78± 72 Wood单位降低到反搏中的 4 76± 85 Wood单位(P<0 .0 5 )。这表明体外反搏可使血管阻力下降 ,血压和血流脉动性增强。Pulsatile blood flow plays an important role in maintaining normal vascular endothelial function. Quantitative measurement of pulsatility of artery blood pressure and blood flow in dogs and effects of enhanced external counterpulsation (EECP) on the pulsatility were taken in this study. Common carotid artery blood pressure and blood flow were measured in 6 beagle dogs that had suffered from an acute myocardial infarction 6 weeks before. A 6F tip transducer catheter was inserted into the right common carotid artery to measure blood pressure, and blood flow was measured in the left common carotid artery by an electromagnetic blood flow probe under anesthesia before and during EECP. Blood pulse pressure, pulsatility index (ratio of peak pressure to end diastolic pressure) and standard deviation of blood pressure were calculated to evaluate the pulsatility of arterial blood pressure. Blood pulse flow, pulsatility index (ratio of peak flow to trough flow) and standard deviation of blood flow were calculated to evaluate the pulsatility of blood flow. Mean vascular resistance (MVR) was calculated as MVR=mean blood pressure / mean blood flow.Blood pulse pressure, pulsatility index and standard deviation of blood pressure were elevated from 30±9 mmHg,1.26±0.05 and 8.7±2.5 mmHg to 43±8 mmHg (P<0.05),1.54±0 13 and 12.4±2.0 mmHg ( P <0.05) before and during EECP,respectively. Blood pulse flow, pulsatility index and standard deviation of blood flow were elevated from 317±48ml/min, 2.85±0.21 and 96±21 ml/min to 447±88 ml/min, 4.56±0.90 and 131±39 ml/min before and during EECP (P<0.05). MVR was decreased from 578±72 before EECP to 476±85 Wood units during EECP( P <0.05).These data demonstrate that EECP gives an elevation of pulsatility to blood pressure and blood flow, thus it may lead to the decrease of vascular resistance.

关 键 词：体外反搏 血流脉动性 冠心病 血管阻力 影响 

分 类 号：R541.4[医药卫生—心血管疾病] R318.01[医药卫生—内科学]