复发性生殖器疱疹患者血清IL-2/IFN-γ水平和NK/LAK细胞活性的变化  

Changes of the serum levels of IL-2/IFN-γ and the activities of NK/LAK cell in patients with RGH

作　　者：田中伟[1] 宋向凤[2] 

机构地区：[1]西安交通大学第二医院皮肤科,陕西西安710004 [2]新乡医学院免疫学教研室,河南新乡453003

出　　处：《免疫学杂志》2002年第B06期32-34,共3页Immunological Journal

摘　　要：目的　探讨RGH患者血清细胞免疫功能的变化。方法　采用PHA诱导淋巴细胞增殖 ,观测淋巴细胞诱导后的增殖能力 ,并测定细胞因子IL 2和IFN γ血清浓度的变化 ;用LDH释放法测定NK和LAK细胞的杀伤活性 ,对结果进行统计学处理。结果　与对照组比较 ,RGH患者对PHA诱导的淋巴细胞增殖能力显著下降 (P <0 .0 5 ) ;血清IL 2和IFN γ水平也显著降低 (P <0 .0 1) ;NK和LAK细胞的杀伤活性亦明显降低 (P <0 .0 1)。结论　RGH患者细胞免疫功能紊乱是其易复发的免疫学发病机制。Objective To investigate the changes of cellular immunity in serum in patients with recurrent genital herpes(RGH). Methods PHA was used to induce the proliferation of lymphocytes. The proliferated ability of lymphocytes was measured with MTT assay. The serum levels of IL 2/IFN γ were detected with ELISA assay. The activities of NK and LAK cell were measured with lactate dehydrogenase (LDH) methods. Results Compared with control group, the proliferated ability of lymphocytes, the serum levels of IL 2 and IFN γ, the activities of NK and LAK cell were significantly lower in the patients with RGH. Conclusion The dysfunction of cellular immunity plays an important role in the immunical pathogenesis of RGH patients.

关 键 词：血清 复发性生殖器官疱疹 IL-2 IFN-Γ LAK细胞活性 细胞免疫 NK细胞 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]