控释硝苯地平降压效应谷 /峰比率的临床研究  

Clinical study on antihypertensive effect trough to peak ratio of nifedipine GITS

作　　者：李玉杰[1] 麦炜颐[1] 曾群英[1] 廖晓星[1] 王礼春[1] 陈国伟[1] 

机构地区：[1]中山医科大学附属第一医院,广州510080

出　　处：《中国临床药理学与治疗学》2001年第2期138-141,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的　探讨计算控释硝苯地平治疗原发性高血压患者降压效应谷 /峰比率 (T/PR)的最佳方法和该药的平稳指数 (SI)。方法　轻、中度原发性高血压患者 32例 ,每天早晨服控释硝苯地平 (nifedip ineGITS) 30mg,治疗前及 4wk后作动态血压监测 ,分别以 2h个体法和整组法计算T/PR并计算该药的SI。结果　 4wk治疗后患者偶测血压和动态血压的降低幅度分别为 (2 4± 12 ) /(12±8)mmHg和 (14 .5± 3.9) /(11.2± 3.1)mmHg;个体法计算的收缩压和舒张压的T/PR分别为0 .6 5± 0 .2 3和 0 .6 6± 0 .2 5 ,而整组法则分别为0 .6 2和 0 .6 8;该药的收缩压和舒张压SI分别为3.74和 3.77。结论控释硝苯地平可 2 4h有效平稳地降压 ;Aim To explore the best way of calculating antihypertensive effect of nifedipine GITS on trough to peak ratio (T/PR), and smoothness index (SI) of the drug from ambulatory blood pressure monitoring (ABPM). Methods 32 cases of mild to moderate essential hypertension patients were enrolled and each was given 30 mg of nifedipine GITS once daily. ABPM was repeated for four weeks. ABPM data were analyzed statistically and T/PR calculated by both individual and whole group way. Results The casual blood pressure(CBP) and ABP were lowered by (24±12)/(12±8) mmHg and ( 14.5 ± 3.9 )/( 11.2 ± 3.0) mmHg .The T/PR by individual way was 0.65 ± 0.23 for SBP and 0.66 ± 0.25 for DBP, while by whole group way 0.62 for SBP and 0.68 for DBP. The smoothness index (SI), a new method for assessing the homogeneity of 24 hour blood pressure reduction by antihypertensive therapy, was 3.74 for SBP and 3.77 for DBP after treatment. Conclusion Nifedipine GITS lowers blood pressure effectively and smoothly for 24 hours long. Antihypertensive effects can be reflected by T/PR and SI.

关 键 词：高血压 谷峰比率 动态血压 平稳指数 控释硝苯地平 

分 类 号：R972.4[医药卫生—药品]