抗凝疗法及氮芥对肾病综合征患者尿量及纤维蛋白原的影响  

The Influence of Urine Volume and Fibrinogen in Nephrotic Syndrome Therapy with Anticoagulant Therapy and Nitrogen Mustard

作　　者：杨涛[1] 曹明亮[1] 姜得训[1] 田向东[1] 李庆[1] 黄萍[1] 刘洪涛[1] 

机构地区：[1]中国人民解放军北京军区总医院肾脏病科,北京100700

出　　处：《中国中西医结合肾病杂志》2002年第6期334-335,338,共3页Chinese Journal of Integrated Traditional and Western Nephrology

摘　　要：目的 :探讨抗凝药物及氮芥对肾病综合征患者尿量及纤维蛋白原的影响。方法 :记录治疗前后患者的尿量及纤维蛋白原的改变 ,对治疗前后有显著差异者进行比较。结果 :尿激酶合氮芥 ,低分子肝素及肝素治疗前后尿量改变明显 (P <0 .0 5 ) ,尿激酶、肝素及低分子肝素可明显降低血浆纤维蛋白原含量 (P <0 .0 5 )。结论 :氮芥合尿激酶 ,肝素与低分子肝素对肾病综合征患者在利尿及降纤治疗上有优势。Objective:To evaluate the influence of anticoagulant therapy and Nitrogen mustard.on urine volume and fibrinogen in patients with nephrotic syndrome.Methods:Changes of urine volume and fibrinogen after the treatment were recorded, and these changes were compared. Results:After the treatment with urokinase plus nitrogen mustard and heparin,the volume of urime obviously increased(P<0.05).These drugs can remarkably lower the conteut of plaswa fibrinogen(P<0.01). Conclusions:The therapeutic methods of combined usage of urokinase with nitrogen mustard,Heparin and Low molecular heparin are superior in promoting diuresis and in lowering the fibrinogen in nephrotic syndrome patients.

关 键 词：抗凝疗法 氮芥 肾病综合征 治疗 尿量 纤维蛋白原 

分 类 号：R692[医药卫生—泌尿科学]