腰腿痛发病机制研究  

Pathological mechanism of low back pain

作　　者：岳寿伟[1] 刘庆[1] 

机构地区：[1]山东大学齐鲁医院,山东济南250012

出　　处：《中国临床康复》2002年第12期1724-1728,1733,共6页Chinese Journal of Clinical Rehabilitation

摘　　要：椎间盘和椎间关节具有多重感觉神经支配,椎间盘的损伤和椎间关节的无菌性炎症产生疼痛,神经根的受压和炎症刺激使疼痛敏化。背根神经节是多种神经肽的制造场所和输送站,神经肽除了维持正常神经信息的传递、对伤害感受性感觉的神经递质的调节外,还具有血管活性作用,诱发神经源性神经肽介导的炎症损伤作用。反复的损伤和炎症刺激,可造成神经根与周围组织的粘连。以上因素均是产生腰腿痛的原因。Both intervertebral disc and facet j oint dominated by duplicated sensory nerve.Injury and sterility inflam mation of them cause low back pain.Nerve root compressed and inflammation stimulated make it hyperalgesia.Dorsal root ganglia i s the place that produce many kind of neuropetide.Neuropetide have many functions,such as transmission of nerve information,adjustmen t neurotransmitter of injury re-ceptor and activity of blood vessel.Injury and stimulated by inflammation repeatedly cause adherence betwe en nerve root and its circumference tissue.Those are result in low back p ain.

关 键 词：腰腿痛 发病机制 炎症损伤 神经源性神经肽 腰椎间盘突出症 

分 类 号：R681.55[医药卫生—骨科学]