过期妊娠产妇外周血和羊水雌二醇及孕酮水平的测定  

Study on the level of estrogen progesterone and the expression of their receptors in the related target tissues in prolonged pregnancy

作　　者：卢凤昕[1] 王自能[1] 

机构地区：[1]暨南大学医学院第一附属医院妇产科,广东广州510630

出　　处：《暨南大学学报（自然科学与医学版）》2002年第2期37-41,共5页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：目的 :测定过期妊娠产妇外周血血清和羊水中的雌二醇 (E2 )、孕酮 (P4 )水平 ,探讨E2 、P4水平变化与过期妊娠及宫缩发动的相关性。方法 :放射免疫法测定过期妊娠与足月妊娠产妇 (各2 0例 )羊水和外周血血清E2 、P4 浓度。结果 :1)过期妊娠组产妇外周血血清和羊水P4 水平明显高于足月妊娠组 (2 0 4 13± 4 1 16vs 176 4 6± 2 4 89,t =2 5 86 ,P <0 0 5 ;10 7 0 6± 2 8 6 6vs 71 2 3±13 6 7,t=5 0 4 6 ,P <0 0 1) ,E2 /P4 值明显低于足月妊娠组 (0 78± 0 17vs 0 90± 0 16 ,t=- 2 2 4 7,P<0 0 5 ;0 19± 0 10vs 0 2 6± 0 0 6 ,t=- 2 5 5 2 ,P <0 0 5 ) ,差异有显著性。 2 )临产组与未临产组产妇外周血血清中E2 、P4 水平及E2 /P4 值均无明显差异 (147 98± 12 0 0vs 16 2 0 5± 2 8 38,t =-1 76 2 ,P >0 0 5 ;175 0 2± 2 2 84vs 198 5 2± 4 0 0 8,t =- 2 0 17,P >0 0 5 ;0 88± 0 18vs 0 82±0 17,t=1 136 ,P >0 0 5 ) ;而临产组羊水中的P4 水平低于未临产组 (74 39± 16 73vs 97 0 9± 30 77,t=- 2 5 5 4 ,P <0 0 5 ) ,E2 /P4 值高于未临产组 (0 2 9± 0 0 9vs0 18± 0 0 6 ,t=- 4 4 41,PAim: This study was designed to determine whether prolonged pregnancy is associated with change of the concentration of estradiol and progesterone in amniotic fluid and maternal serum. Methods: Maternal serum and amniotic fluid samples were assayed for estradiol and progesterone by radioimmunoassay. Results: As compared with the term pregnancy, the concentration of progesterone in amniotic fluid of prolonged pregnancy was significantly higher and the estrogen-progesterone receptor ratio was lower in the women not in labor.(204.13±41.16 vs 176.46±24.89, t=2.586 P<0.05; 107.06±28.66 vs 71.23±13.67,t=5.046,P<0.01),(0.78±0.17 vs 0.90±0.16 ,t=-2.247, P<0.05; 0.19±0.10 vs 0.26±0.06, t= -2.552 ,P<0.05). In contrast, no significant differences of estradiol, progesterone concentration and estradiol-progesterone ratio in maternal serum were detected between the women in labor and not in labor. However, the progesterone concentration in amniotic fluid were lower found in the women in labor than those not in labor, but estradiol-progesterone ratio were found higher(74.39±16.73 vs 97.09±30.77,t=-2.554,P<0.05), (0.29±0.09 vs 0.18±0.06,t= -4.441 ,P<0.01). Conclusion: The lower estradiol-progesterone ratio was related with prolonged pregnancy, and the higher estradiol-progesterone ratio was associated with the onset of labor.

关 键 词：雌二醇 孕酮 过期妊娠 分娩 

分 类 号：R714.21[医药卫生—妇产科学]