组织学配型与肾移植效果的影响因素(综述)  

The effective factors in organic matching of kidney transplantation (A review)

作　　者：尹良红[1] 郑绮宜[1] 陈湛华[1] 蔡启德[1] 朱宁[1] 王平[2] 

机构地区：[1]暨南大学医学院附属一院肾内科,广东广州510630 [2]暨南大学医学院附属一院肾移植科,广东广州510630

出　　处：《暨南大学学报（自然科学与医学版）》2002年第2期79-83,共5页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：HLA抗原系统分为Ⅰ类抗原 (A、B、C)和Ⅱ类抗原 (DR、DP、DQ)。国内外的临床研究资料表明 ,HLA配型在改善肾移植效果方面起着重要作用。不同位点的HLA抗原所起的作用不同 ,其重要性为DR >B >A >C。良好的HLA配型 ,特别是DR位点的相合 ,可明显改善高群体反应性抗体(PRA)受者的肾移植效果。In process of studing the relationship between HLA and rejection in renal transplantation, it has been discovered that proper HLA matching between donors and recipient can reduce graft rejection. HLA antigen include HLA class I(A,B,C) and HLA class Ⅱ (DR, DP, DQ), the different antigens of different locus have a variety of effects. Good HLA matching will improve the survival of kidney absolutely. The importance of different HLA locus is DR>B>A>C. Good HLA matching plays an important role in reducing the incidence of acute rejection and in improving the survival of grafts, particularly for recipient having high PRA.

关 键 词：组织学配型 肾移植 人白细胞抗原 

分 类 号：R699.2[医药卫生—泌尿科学]