HPLC法测定盐酸西替利嗪片的含量  

DETERMINATION OF CETIRIZINE HYDROCHLORIDE TABLETS BY HPLC

作　　者：杨敏[1] 

机构地区：[1]深圳市药品检验所,深圳518029

出　　处：《中国药品标准》2002年第3期28-29,共2页Drug Standards of China

摘　　要：目的:建立HPLC法测定盐酸西替利嗪片的含量。方法:色谱条件:C_(18)柱,甲醇-水-三乙胺-磷酸(700:300:5:6.5)(pH3.5)为流动相,咖啡因为内标物,检测波长为230nm。结果:平均回收率为99.85％,RSD=0.45％(n=6);线性范围:20.64～103.2μg/ml,r=0.9999。结论:该法准确,可靠,能满足质量控制的要求。Objective: To establish the method of the determination of cetirizine hydrochloride tablets. Method: The HPLC with C_(18)column,mobile phase of methanol-water-triethytamine-phospheric acid(700: 300:5:6.5)(pH3.5),detection wavelength of 230nm and caffeine as interal standard were used.Results: The average recovery rate of the method was 99.85%,RSD was 0.45%(n=6),The rang of linear corellation it was 20.64～103.2μg/ml,r=0.9999.Conolusion:The method was accurate and reliable,it can be used for the assay of cetirizine hydrochloride tablets.

关 键 词：HPLC 盐酸西替利嗪 含量测定 选择性组胺H1受体拮抗剂 

分 类 号：R927.2[医药卫生—药学] R976