三硝基甲苯血红蛋白加合物与接触量的关系  

The relationship between hemoglobin adducts of trinitrotoluene and exposed level

作　　者：宋文佳[1] 王雅文[1] 闫慧芳[1] 冷曙光[1] 谷也平[1] 刘玉瑛[1] 郑玉新[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所毒理学研究室,北京100050

出　　处：《中华劳动卫生职业病杂志》2002年第3期189-191,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：欧盟合作课题(ERB3514PL961376)

摘　　要：目的探讨反映三硝基甲苯(TNT)接触水平的生物标志物,研究TNT作业工人体内的血红蛋白加合物与接触量的关系。方法使用GC-MS法测定25名TNT作业工人血液中TNT血红蛋白加合物(4A-Hb、2A-Hb)的含量,观察其与接触量的相关性。接触水平以空气污染量和皮肤污染量表示。结果血红蛋白加合物4A-Hb、2A-Hb与总接触水平相关,尤其与皮肤接触量相关性更强;其中4A-Hb与总接触水平的回归曲线和血红蛋白加合物总量(4A-Hb+2A-Hb)与总接触水平的回归曲线的斜率(F=0.03)及截距(F=0.11)的差异均无显著性(P>0.05)。结论血红蛋白加合物4A-Hb、2A-Hb均可用于评价TNT总接触水平,其中4A-Hb更适宜评价TNT的接触水平。Objective To explore the biomarkers for monitoring trinitrotoluene(TNT)exposure,the rela-tionship between TNT hemoglobin adducts and TNT exposed level.Method Hemoglobin adducts(4A-Hb and2A-Hb )were determined by GC-MS in25TNT exposed workers.TNT exposed level was evaluated by determin-ing skin contaminated and inhaled TNT levels.The correlation between hemoglobin adducts level and TNT exposed level was analyzed.Results There was a correlation between total TNT exposure level,especially skin exposure level,and4A-Hb or2A-Hb content.No significant difference was found between the slopes and intercepts of lin ear equation of(4A-Hb )vs TNT exposed level and linear equation of(4A-Hb +2A-Hb )vs TNT exposed level(P>0.05).Con clu sion Skin contamination is the major role of TNT exposure.TNT exposed level can be evalu-ated by determining the content of both4A-Hb and2A-Hb ,and4A-Hb is more suitable for monitoring TNT expo-sure.[

关 键 词：三硝基甲苯 血红蛋白加合物 接触剂量 职业危害 

分 类 号：R135[医药卫生—劳动卫生]