尿邻甲酚作为接触甲苯生物监测指标的探讨  

Evaluation of urinary ortho-cresol as biological monitoring indicator of occupational exposure to toluene

作　　者：米亚娴[1] 刘黛莉[1] 李志华[1] 李建国[1] 罗毅[1] 扈健[1] 

机构地区：[1]天津市卫生防病中心理化部,300011

出　　处：《中华劳动卫生职业病杂志》2002年第3期200-202,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：天津市卫生局自然科学基金资助项目(97KY41)

摘　　要：目的探讨尿邻甲酚作为接触甲苯生物监测指标的可能性。方法建立柱前衍生高效液相色谱法测定人体尿中邻甲酚,且使用该方法测定非职业及职业接触甲苯人群尿中邻甲酚水平,并进行接触评定。结果甲苯接触者尿邻甲酚水平为(2.61±1.94)mg/L,明显高于对照组[(0.32±0.23)mg/L],差异有显著性(P<0.001),且接触甲苯工人班后尿邻甲酚水平比班前明显升高,最高可达29倍。接触甲苯者尿邻甲酚水平与个体接触甲苯浓度明显相关(r=0.6295,P<0.01)。结论尿邻甲酚可以作为接触甲苯的生物监测指标。Objective To investigate the feasibility of urinary ortho-cresol levels as a biological monitor ing indicator for toluene exposure.Methods Establish pre-column derivation HPLC method to detect ortho-cresol levels in urine of human body.Ortho-cresol levels in urine of workers non-exposed and exposed to toluene was ex-amined using this pre-column derivation HPLC method,and exposure assessment was conducted.Results It was shown that urinary ortho-cresol level in exposed workers was(2.61±1.94)mg/L,higher than those of control group[(0.32±0.23)mg/L,P<0.001].Urinary ortho-cresol level in exposed workers at the end of a workshift was high-er than those before exposure to toluene,and also was correlated with the concentration of toluene to which individual exposed(r=0.6295,P<0.01).Con clu sion Urinary ortho-cresol as a biological monitoring indicator for toluene exposure is feasible.[

关 键 词：尿 邻甲酚 接触 甲苯 生物监测 职业接触 

分 类 号：R135[医药卫生—劳动卫生]