左旋四氢巴马汀的降压作用  

HYPOTENSIVE AND α-ADRENOCEPTOR BLOCKING ACTIONS OF L-TETRAHYDROPALMATINE

作　　者：姚兵[1] 卞春甫[1] 秦伟[1] 

机构地区：[1]徐州医学院药理学教研室

出　　处：《徐州医学院学报》1991年第1期16-19,共4页Acta Academiae Medicinae Xuzhou

摘　　要：1-THP 2.5、5.0、10.0、20.0mg/kgiv均使大鼠出现明显的降低动脉血压作用,并呈剂量依赖关系,在降压的同时伴短暂的心率减慢。1-THP 30mg/kgip或1-THP 60.00mg/kgpo同样可降低大鼠动脉血压。1-THP5.0mg/kgiv能拮抗NE对大鼠的升压作用,使其量效曲线右移,最大反应不压低,1-THP 20.0mg/kgiv可翻转Adr的升压作用。提示1-THP有降压作用,其机理可能部分与阻滞α受体有关。Intravenous injection of 1-tetrahydroplamatine ( 1-THP)2.5, 5.0, 10.0 and 20.0 mg/kg lowered the blood Pressure in rats revealed a dose-de-Pendent relationship. The heart rate was slightly slowed along with the lowering of blood Pressure. 1-THP 30 mg/kg iP or 60 mg/kg Po decreased the rat blood Pressure as well. The hypertensive action of NE was antagonized by 1-THP 5.0 mg/kg and its dose-effect curve was shifted to the right, but the Emax of NE was not reduced. 1 -THP 20.0 mg/kg iv reversed the Pres-sor action of adrenaline. These results indicate that 1 -THP can decrease blood Pressure and the machanism may be related to the blocking of α-adre-nocePtors.

关 键 词：1-THP Α-受体 血压 

分 类 号：R966[医药卫生—药理学]