兰州地区乙肝病毒基因亚型的感染情况  

Genotypes of HBV Infection in Lanzhou China

作　　者：李天一[1] 陈青锋[2] 肖萍[2] 郭振华[2] 杨彦麟[2] 高评[2] 

机构地区：[1]兰州医学院,兰州,730000 [2]兰州医学院附属第一医院感染科

出　　处：《临床消化病杂志》2002年第3期99-100,共2页Chinese Journal of Clinical Gastroenterology

摘　　要：目的 :调查兰州地区乙肝病毒基因分型情况及其和性别、血清标志物的关系。方法 :用PCR 微板核酸杂交 ELISA法对 88例兰州地区慢性无症状携带者 (AsC)及慢性乙型肝炎 (CHB)、肝炎后肝硬化 (HLC)的HBVDNA进行基因分型 ,并用酶免疫法 (EIA)测其血清标志物 (HBV M )。结果 :兰州地区基因型C型 67 0 % ,B型 12 5 % ,B、C混合型18 2 % ,其他型 2 3 %。男、女性感染HBVDNA构成比存在差异 ,HBeAg阳性率C型较B型高。结论 :兰州地区的基因型以C型为主 ,乙肝病毒基因亚型易感性可能存在性别差异 ,不同基因亚型感染可形成不同的血清标志物。Purpose: To investigate the genotypes of HBV DNA infecton in Lanzhou China and relationships between genotype and sex, HBV M. Methods: We classified HBV DNA of 88 AsC? CHB? HLC living in Lanzhou by using PCR Microplate sandwith hybridization ELISA technique, whose HBV M were detected by EIA. Results: Among them, genotype C was 67.0%, genotype B 12.5%, mixed genotype B and C 18.2%, genotype A or D 2.3%. Proportion of genotypes between male and female was different. Positive rate for HBeAg of genotype C was higher than that of genotype B. Conclusion: Genotype C is the main genotype in Lanzhou. Susceptibility of HBV may have difference of sex. Infection of HBV of different genotype forms different HBV M.

关 键 词：乙肝病毒 基因分型 血清标志物 乙型肝炎 

分 类 号：R512.62[医药卫生—内科学]