原花青素体外清除自由基活性的研究  

Scavenging Activity of Procyanidins on Free Radicals

作　　者：余莹[1] 粟武[1] 魏东芝[1] 

机构地区：[1]华东理工大学生物化学研究所,上海200237

出　　处：《华东理工大学学报（自然科学版）》2002年第3期318-320,共3页Journal of East China University of Science and Technology

摘　　要：从葡萄籽中提取高纯度的原花青素 ,测得其对稳定自由基 1 ,1 -联苯 -β-苦基偕腙肼( DPPH)的半数抑制浓度 ( EC50 )为 44mg/L ;又利用 2 -脱氧 - D-核糖法产生· OH,在原花青素浓度为 1 0 g/L时可清除该体系中 80 %的· OH。The purified procyanidins were obtained from grape seeds and its scavenging activity on DPPH and hydroxyl radicals was determined. The results showed that the 50% scavenging concentration ( EC 50 ) was 44mg/L in the DPPH and 80 percentage hydroxyl radicals was scavenged when the concentration was 10g/L. These results suggested that procyanidins would be a effective natural free radical scavenger.

关 键 词：原花青素 自由基 活性 葡萄籽 DPPH 抗氧剂 植物药 

分 类 号：R282.71[医药卫生—中药学]