核因子κB的跨核膜转运及其调控机制  

Nucleocytoplasmic Transport of Nuclear Factor κB and Its Regulatory Mechanisms

作　　者：沈利群[1] 徐祥[1] 吕凤林[1] 梁华平[1] 

机构地区：[1]第三军医大学附属大坪医院野战外科研究所

出　　处：《生物化学与生物物理进展》2002年第3期368-371,共4页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展规划项目 (973 ) (G19990 5 42 0 3 ) ;国家自然科学基金资助项目 (3 0 0 80 0 0 9);重庆市科委基金项目(2 0 0 0 63 19) .~~

摘　　要：核因子kappaB (NF κB)是一组重要的转录调节因子 ,当细胞处于静息状态时 ,它与抑制蛋白IκB结合以非活性的形式存在于胞浆中 .当细胞受到多种外界信号刺激 ,NF κB、IκB分别在核定位信号 (NLS)的介导下经核孔复合物 (NPC)转运入核 .在核内 ,NF κB与IκB再次结合成复合物 ,在核转出信号 (NES)介导下 ,经CRM 1依赖的途迳出核 .该过程是能量依赖的主动转运过程 。Nuclear factor κB(NF κB) is an important transcriptional factor and maintains in a cytoplasmically localized inactive state by the inhibitory protein κB(IκB). Following stimulation, NF κB and IκB import into nucleus through nuclear pore complexes(NPC),mediated by nuclear localization signal(NLS), respectively. In nucleus, IκB binds to NF κB again. Dependent on the CRM1 pathway, the complexes export from nucleus to cytoplasm, mediated by nuclear export signal(NES). Nucleocytoplasmic transport of complexes is an energy dependent process which involves small Ran protein and several soluble factors.

关 键 词：核因子КB 跨核膜转运 调控机制 

分 类 号：Q735[生物学—分子生物学] Q26