自发性高血压鼠脑底动脉神经肽Y能神经纤维的起源  

ORIGIN OF THE NEUROPEPTIDE Y-CONTAINING NERVE ON CEREBRAL VESSELS IN SPONTANEOUSLY HYPERTENSIVE RATS

作　　者：林雪群[1] 杨刚[2] 邵立健[1] 石嘉庆[1] 

机构地区：[1]江西医学院解剖学教研室,南昌330006 [2]江西医学院第二附属医院普外科,南昌330006

出　　处：《中国组织化学与细胞化学杂志》2001年第2期142-145,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：卫生部科研基金资助项目!(No. 98- 1- 337);江西省自然科学基金资助项目

摘　　要：应用免疫组织化学 ABC法和神经节切除术 ,观察了 16只自发性高血压鼠 (分手术 、 、 组和对照组 )脑底动脉主要分支神经肽 Y能神经纤维的起源。对照组自发性高血压鼠大脑前动脉、大脑中动脉、大脑后动脉和基底动脉壁上均可见棕褐色的神经肽 Y能阳性纤维 ,纤维似曲线状 ,多呈网状走行 ,密度较高。手术 组作双侧颈上神经节切除术 ,脑底动脉主要分支的阳性纤维明显减少 ,但不完全消失 ;手术 组作双侧星状神经节切除术 ,脑底动脉主要分支壁上的阳性纤维明显减少 ;手术 组作双侧颈上神经节和星状神经节切除术 ,脑底动脉主要分支的阳性纤维完全消失。结果提示 :自发性高血压鼠脑底动脉主要分支神经肽 Y能神经纤维起源于双侧颈上神经节和星状神经节。讨论了Origin of the neuropeptide Y containing nerves on cerebral vessels in 16 spontaneously hypertensive rats(SHR) (divided into control group and operating 3 groups) were studied with ganglionectomy and ABC immunoperoxidase techniques, employing neuropeptide Y(NPY) as label. The immunoreactive positive fibers with the brown lineal structures were observed on the anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA) and basilar artery (BA) in control group′s SHR. Operating I group with bilateral superior cervical ganglionectomy, 10~14 day later, immunoreactive positive fiber′s density on bilateral ACA、MCA、PCA and basilar artery (BA) obvious decreased, but not disapp lyear fully. Operating Ⅱ group with bilateral stellectomy, 10~14 day later, immunoreactive positive fiber′s density on bilateral ACA、MCA、PCA and basilar artery (BA) decreased obviously. Operating Ⅲ group with bilateral stellectomy and superior cervical ganglionectomy at same time, 10~14 day later, immunoreactive positive fiber′s density on bilateral ACA、MCA、PCA and basilar artery (BA) almost disappear completely. Statistics t test analysis immunoreactive positive fiber density among operating Ⅰ、Ⅱ、Ⅲ group and control group, P <0 01, indicating significant difference among operating Ⅰ、Ⅱ、Ⅲ group and control group. The results suggested that neuropeptide Y containing nerve fibers on unilateral in cerebral vessels of the SHR originated bilateral superior cervical ganglion and stellecte ganglion, and the role of the neuropeptide Y containing nerves in the maintenance and development of hypertension in SHR were discussed.\;

关 键 词：脑动脉 大鼠 Y能神经纤维 自发性高血压 脑底动脉 神经肽 

分 类 号：R544.1[医药卫生—心血管疾病]