超广谱β-内酰胺酶细菌医院感染调查  

Nosocomial Infection Based on Extended Spectrum β- Lactmases Bacilli

作　　者：马健[1] 张延霞[1] 贺立新[1] 

机构地区：[1]解放军第304医院,北京100037

出　　处：《中华医院感染学杂志》2002年第6期422-424,共3页Chinese Journal of Nosocomiology

摘　　要：目的　研究产超广谱β-内酰胺酶 (ESBL s)的革兰阴性菌引起的医院感染发生率 ,为临床防治对策提供依据。方法　分析了于 1999年 5月～ 2 0 0 0年 7月间由产 ESBL s革兰阴性菌引起医院感染。结果　产 ESBL s革兰阴性菌的医院感染细菌多见于肺炎克雷伯菌 ,占 5 7.15 % ,其次为大肠埃希菌、阴沟肠杆菌等 ,约各占 14 .2 5 % ;研究发现 ,此感染多见于那些健康等级差、住 ICU病房、烧伤及机体抵抗力差的患者中 ,并与长期住院和应用广谱抗生素有明显关系。结论　产 ESBL s革兰阴性菌在医院中的感染正日益增多 ,尤其多见于长期住院、应用广谱抗生素、住 ICU病房的患者中 ;亚胺培南是目前少数对 ESBL s高度稳定的品种之一。OBJECTIVE To investigate the prevalence ratio of nosocomial infection caused by ESBL producing Gram negative bacilli, and to provide the corresponding clinical prevention strategies. METHODS The survey is based on the analysis of a number of collected nosocomial infection cases related to ESBL producing Gram negative bacilli from 1999.5 2000.7. RESULTS From of the main organisms nosocomial infection, Klebsiella pneumoniae accounted for 57.5%, in addition Enterobacteria and Escherichia coli for 14.25%, respectively. Patients widely exist in those populations with poor health. It is also found that the long term clinical treatment and broad spectrum antibiotic therapy are responsible for such infection. CONCLUSIONS There has been increasingly occurred nosocomial infection of ESBL producing Gram negative bacilli, particularly as the treatment is of long term, and meanwhile the broad spectrum antibiotic therapy is applied. Imipenem is currently the one of a few of products with highly stable character in respect to ESBLs.

关 键 词：医院内感染 超广谱Β-内酰胺酶 调查 

分 类 号：R181.34[医药卫生—流行病学]