乙酰肝素酶——细胞与基质间相互作用的新型调节剂  

Heparanase——a novel regulator for cell and matrix interactions

作　　者：吴建秋[1] 景在平[1] 

机构地区：[1]第二军医大学长海医院血管外科,上海200433

出　　处：《中国病理生理杂志》2002年第5期580-583,共4页Chinese Journal of Pathophysiology

摘　　要：Dynamic interactions between cells and underlying extracellular matrices are crucial for development, maintenance of cellular function, and response of tissure to injury and infection. Heparan sulfate proteoglycans(HSPG)are found in extracellular matrices and on the surface of most nuclrarated cells, and play critical roles in cell-cell and cell-matrix signal transduction by binding many molecules, such as growth factors and cytokines. Most of the biological properties of HSPG are conferred by heparan sulfate side chains, which can be degraded by heparanase. Changes of heparanase expression and activity may affect the biological processes above, which enables extravasation of inflammation cells, metastasis and neoangiogenesis of tumor cells invasion.Dynamic interactions between cells and underlying extracellular matrices are crucial for development, maintenance of cellular function, and response of tissure to injury and infection. Heparan sulfate proteoglycans(HSPG)are found in extracellular matrices and on the surface of most nuclrarated cells, and play critical roles in cell-cell and cell-matrix signal transduction by binding many molecules, such as growth factors and cytokines. Most of the biological properties of HSPG are conferred by heparan sulfate side chains, which can be degraded by heparanase. Changes of heparanase expression and activity may affect the biological processes above, which enables extravasation of inflammation cells, metastasis and neoangiogenesis of tumor cells invasion.

关 键 词：乙酰肝素酶 相互作用 调节剂 细胞外基质 硫酸乙酰肝素蛋白多糖 

分 类 号：Q539[生物学—生物化学]