黄连水煎剂对未孕大鼠子宫平滑肌电活动的作用及其机制研究  

Study on effects of Rhizoma coptidis decoction on myoelectric activity of uterine smooth muscle of unpregnancy rats and its action mechanism

作　　者：鲁彦[1] 秦晓民[1] 徐敬东[1] 李德红[2] 

机构地区：[1]兰州医学院生理教研室,甘肃兰州730000 [2]甘肃省人民医院检验科,甘肃兰州730000

出　　处：《中成药》2002年第6期444-446,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :探讨黄连水煎剂对大鼠子宫平滑肌电活动的作用及机制。方法 :在大鼠子宫浆膜层包埋一对微型Ag AgCl电极 ,用Biolop98生物机能系统记录子宫肌电活动 ,观察腹腔注射黄连水煎剂对大鼠子宫平滑肌电活动的作用以及M受体、组胺H1受体、α受体、L型钙通道及前列腺素合成酶分别被阻断或抑制后这种作用受到影响。结果 :黄连水煎剂可以显著增强大鼠子宫平滑肌电活动 ,阻断M受体与H1受体后 ,该作用部分减弱 ;阻断L型钙通道后 ,该作用基本消失 ;阻断α受体及抑制前列腺素合成酶后 ,该作用不受影响。结论 :低、中、高剂量黄连水煎剂均可不同程度增强大鼠子宫平滑肌电活动 ,该作用可能通过M受体、组胺H1受体及L型钙通道发挥作用 ,与α受体及前列腺素的合成。Objective:To observe the effects of Rhizoma coptidis decoction on the myoelectric activity of womb of virginal rats and to discuss its mechanism. Methods: The changes of uterine myoelectric activity of rats were recorded by Biolap 98 biological system with a pair of mini bipolar Ag AgCl electrodes implanted on the uterine serosal surface. Rhizoma coptidis decoction was injected to find their effects on uterine myoelectric activity of rats, then M, H 1,α,L calaium channel and prostaglandin synthetase were blocked or inhibited respectively to be observed their influence Rhizoma coptidis decoction. Results:Rhizoma coptidis decoction can significantly increase uterine myoelectric activity of rats. After M and H 1 receptors were blocked, the effects of Rhizoma coptidis decoction were partially decreased. The effects of Rhizoma coptidis decoction were disappeared with L calcium channels blocked. But, nothing happened if α receptor was blocked or prostaglandin synthetase was inhibited. Conclusions: Rhizoma coptidis decoction can significantly increase uterine myoelectric activity of rats, which may be associated with M receptor, H receptor and L calcium channels, nothing with α receptor and synthesis or releasing of prostaglandin.

关 键 词：黄连水煎剂 未孕大鼠 子宫平滑肌 电活动 机制 研究 

分 类 号：R285.5[医药卫生—中药学]