早产儿用面罩给氧后抗氧化水平的变化  

Change of Antioxidative Level in Prematures after Face-masked Oxygen Supply

作　　者：胡春华[1] 涂前慧[1] 胡腊先 雷引娣 

机构地区：[1]华中科技大学同济医学院附属同济医院儿科,武汉430030

出　　处：《中国康复》2002年第2期92-93,共2页Chinese Journal of Rehabilitation

摘　　要：目的 :了解早产患儿氧化应激反应能力 ,以指导临床合理用氧。方法 :6 0例早产儿分为 3组 ,AB 2组均给氧治疗 ,C组不用氧。治疗前后监测 3组血浆中谷胱甘肽 (GSH)和丙二醛 (MDA)值。结果 :AB 2组血浆GSH含量均低于C组 ,给氧时间越长 ,氧浓度越高 ,GSH含量越低 ;AB 2组MDA均高于C组 ,且随着氧浓度和给氧时间的增加而增高。结论 :早产患儿对高氧暴露的反应能力低下 ,长时间高浓度的氧疗可使其抗氧化能力降低 ,即使在面罩给氧下氧化和抗氧化的动态平衡也有改变 ,如产生的自由基超过机体的清除能力 ,机体将受到相应损害。Objective: To know the oxidative stress reaction of the prematures so as to guide the rational usage of oxygen. Methods: Sixty prematures were divided into 3 groups: groups A and B received the therapy of oxygen supply, while group C didn't received oxygen supply. Before and after treatment, GSH and MDA were monitored in the 3 groups. Results: In the groups A and B, the content of GSH was lower than in the control group in time and concentration dependent manners. The content of MDA in the groups A and B was higher than in the group C in time and concentration dependent manners. Conclusion: The prematures had a low reaction ability to high oxygen exposure. Long term oxygen therapy with high concentration could decrease the antioxidative ability. It was recommended to rationally supply oxygen clinically.

关 键 词：早产儿 面罩给氧 抗氧化水平 谷胱甘肽 丙二醛 GSA MDA 

分 类 号：R459.6[医药卫生—治疗学]