一锅法高产率合成α-羰基苯丁酸  

One Pot Synthesis of 2-Oxo-4-phenylbutyric Acid in High Yield

作　　者：胡惟孝[1] 赵金浩[1] 周卫[1] 杨忠愚[1] 

机构地区：[1]浙江工业大学制药工程研究所,浙江杭州310014

出　　处：《精细化工》2002年第5期289-290,294,共3页Fine Chemicals

基　　金：浙江省自然科学基金资助项目 (2 0 0 0 16)

摘　　要：用苯丙酸乙酯与草酸二乙酯合成α 羰基苯丁酸。采用一锅法代替文献中的两步反应 ,用稀硫酸代替文献中盐酸 -醋酸混酸水解 ,并用正交设计法对工艺条件进行优化 ,得出最佳工艺条件为 :n(苯丙酸乙酯 )∶n (草酸二乙酯 ) =1 0∶4 0 ,缩合 1 5h ,用w (H2 SO4) =2 0 %的硫酸水解15h ,产品收率由文献值的 5 7 2 %提高到 89%Synthesis of 2 oxo 4 phenylbutyric acid was conducted in one pot.Ethyl 3 phenylpropionate condensed with diethyl oxalate in the presence of sodium methoxide,then the reaction mixture was hydrolyzed with dilute sulfuric acid directly.The optimum reaction conditions were: m (ethyl 3 phenylpropionate)∶ m (diethyl oxalate)=1∶4,time of condesation 1 5 h and hydrolysis for 15 h with sulfuric acid 〔w(H 2SO 4)=20%〕. The yield reached as high as 89% as compared with 57 2% in the literature.

关 键 词：α-羰基苯丁酸 苯丙酸乙酯 草酸二乙酯 

分 类 号：TQ245.6[化学工程—有机化工]