硬膜外腔注入吗啡镇痛剂量的探讨  

Optimum Dose for Epidural Administration of Morphine

作　　者：巩建文[1] 

机构地区：[1]山西医科大学第三医院,山西太原030053

出　　处：《山西职工医学院学报》2002年第2期15-16,共2页Journal of Shanxi Medical College for Continuing Education

摘　　要：目的 :探讨了吗啡用于硬膜外腔镇痛的最佳剂量。方法 :择期腹部手术病人 15 0例 ,随机分为三组 ,每组 5 0例。A组硬膜外腔注入吗啡 5 μg kg;B组硬膜外腔注入吗啡 10 μg kg ;C组硬膜外腔注入吗啡 15 μg kg。观察三组病人的镇痛效果、镇痛持续时间及副作用的发生率。结果 :三组病人术后镇痛效果均满意。术后镇痛持续时间 :A组最短 ,B、C二组相似 ;A与B、C二组相比有差异 (P <0 0 1)。副作用 :A、B二组相似 (P >0 0 5 ) ;C组副作用明显大于A、B二组(P <0 0 1)。结论 :10 μg kg吗啡运用于术后镇痛 ,效果满意 ,副作用少 。Objective To investigate the optimum dose for epidural administration of morphine.Methods 150 patients having abdominal operation were randomly divided into three groups.Group A(n=50) were given morphine by epidural administration with a dose of 5 μg/kg,Group B 10 μg/kg,Group C 15 μg/kg.These patients were carefully observed for pain relief,for duration of pain relief,and for side effects of the drug.Results The pain relief proved favourable in the three groups.Postoperative pain relief lasted for the shortest time in Group A,whereas it was found similar in Group B and Group C.There was a difference between Group A and Groups B and C( P <0.01).Side effects proved greater in Group C than in Groups B and C( P <0 01);they were found similar in the second and the third group.( P >0.05).Conclusion l0 μg/kg may be the best dose for postoperative pain relief.

关 键 词：硬膜外腔 吗啡 术后镇痛 用药剂量 

分 类 号：R619[医药卫生—外科学] R614[医药卫生—临床医学]