大鼠心钙反常灌流液中丙二醛等物质含量变化  

CONTENT CHANGES OF MALONDIALDEHYDE AND OTHER MATERIALS IN PERFUSION FLUID OF ISOLATED RAT HEART DURING CALCIUM PARADOX

作　　者：罗涵[1] 郭殿林[2] 罗正曜[1] 郭立武[1] 詹琼珊 陈广文[1] 

机构地区：[1]湖南医科大学病理生理学教研室 [2]蚌埠医学院病理生理教研组

出　　处：《湖南医科大学学报》1989年第4期328-330,共3页Bulletin of Hunan Medical University

基　　金：国家自然科学基金

摘　　要：用Langendorff方法复制大白鼠离体心钙反常模型,收集冠脉流出液并测定其中丙二醛(MDA)、超氧化物歧化酶(SOD)和乳酸脱氢酶(LDH)的含量。结果表明,钙反常组与对照组比较,复钙期SOD与LDH显著增多(P<0.01),而MDA未见改变,故不支持氧自由基参与无钙灌注5min后复钙灌注引起的钙反常损伤的说法。This study was designed to investigate whether the calcium paradox is associated with oxygen-free radicals. Malondialdehyde (MDA) , superoxide dismatase (SOD) and lactate dehydrogenase (LDH) in coronary effluent were measured.The results showed that contents of effluent MDA, SOD and LDH were unchanged during the calcium-depletion phase, and that reperfusion with calcium resulted in an immediate and massive release of SOD and LDH, but MDA was unchanged.These observations do not suggest that calcium paradox of the heart after 5min.calcium-free perfusion is associated with the oxygen free radicals.

关 键 词：钙 心律不齐 病理生理学 动物 

分 类 号：R541.702[医药卫生—心血管疾病]