21d头低位卧床对人体左心舒张功能的影响  

Effects of 21 d -6° Bed Rest on Diastolic Function of Human Left Ventricle.

作　　者：谈诚[1] 蒋昌林[1] 汪娜[2] 梁文彬[1] 姜世忠[1] 

机构地区：[1]航天医学工程研究所,北京100094 [2]中国人民解放军466医院,北京100040

出　　处：《航天医学与医学工程》2002年第3期182-185,共4页Space Medicine & Medical Engineering

基　　金：国家 8 6 3资助项目 ( 86 3 2 4 2 4)

摘　　要：目的观察模拟失重条件对人体左心舒张功能的影响 ,探讨其在航天后心血管功能失调中的作用。方法采用超声多谱勒技术观察了 6名健康青年男性在 2 1d - 6°头低卧位模拟失重前、实验第 1 0、2 1天及实验后左心舒张功能变化 ,同时检查其卧床前后的立位耐力改变。结果被试者左心舒张功能指标 :经二尖瓣血流E峰最大流速 (PEV)、A峰最大流速 (PAV)、E峰血流速度积分 (VTIE)指标在实验第1 0、2 1天均较实验前有明显的降低 (P <0 .0 5 ) ;而A峰血流速度积分 (VTIA) ,峰值血流速度比值 (A/E)及血流速度积分比值 (VTIA/E)的下降则未达到显著水平 (P >0 .0 5 )。 6名被试者均未能通过立位耐力检查。Objective To investigate the effects of head down bed rest(HDBR),the simulated weightlessness, on the diastolic function of human left ventricle, and to discuss its role in cardiovascular deconditioning after space flight. Method Six healthy young volunteers were subjected to -6° HDBR for 21 d. Ultrasound Doppler technique was used to examine the changes of the diastolic function before, on the 10th, and 21st day during and 2nd day after HDBR. The orthostatic tolerance was also tested before and after HDBR. Result Peak E wave velocity(PEV), peak A wave velocity(PAV), and velocity total integration of E wave(VTI E), were significantly decreased (P<0.05)on the 10th and 21st day during and the 2nd day after HDBR, and velocity, total integration of A wave(VTI A), ratio of E/A, and ratio of VTI E/A were also decreased, but did not reach the significant level(P>0.05). None of the six subjects passed the orthostatic tolerance test after HDBR. Conclusion Simulated weightlessness can induce marked decline in diastolic function of human left ventricle.

关 键 词：头低位卧床 心血管功能 失调 左心室舒张功能 超声多谱勒 模拟失重 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]