辛伐他汀对一氧化氮缺乏性高血压大鼠心脏局部肾素血管紧张素系统的影响  

Effects of simvastatin on local rennin-angiotensin system of heart in NO-deficient hypertensive rats

作　　者：易春涛[1] 程晓曙[1] 俞建华[1] 鄢定红[1] 苏海[1] 吴清华[1] 

机构地区：[1]江西医学院第二附属医院心内科,南昌330006

出　　处：《中国临床药理学与治疗学》2002年第3期227-230,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：江西省自然科学基金资助项目

摘　　要：目的 :观察辛伐他汀对一氧化氮 (NO)缺乏性高血压大鼠心脏局部肾素血管紧张素系统(RAS)的影响。方法 :2 4只Wistar大鼠随机分为正常对照组 (C组 )、硝基精氨酸甲酯 (L NAME)组 (L组 )和L NAME +辛伐他汀组(L+S组 )。每 2wk尾袖法测定动脉收缩压 ,8wk后测定血清甘油三酯(TG)、总胆固醇 (TC)及血清和心肌组织血管紧张素Ⅱ(AngII)水平、血管紧张素转换酶 (ACE)活性。结果 :L组大鼠血压与同期C组血压相比有极显著性差异 (P <0 .0 1 ) ,辛伐他汀干预未对增高的血压产生明显影响(P >0 .0 5 ) ;各组大鼠血清TG和TC水平比较也无显著性差别 (P >0 .0 5 )。与C组相比 ,L组大鼠血清ACE活性明显降低 (P <0 .0 1 ) ,L组和L+S组大鼠血浆AngII水平与C组比较无显著性差异 (P >0 .0 5 ) ,心肌组织中AngⅡ水平和ACE活性则较C组明显增高 (P <0 .0 1 ) ;辛伐他汀干预后L+S组大鼠血清ACE活性升高 ,但与L组无显著性差异 (P >0 .0 5 ) ,心肌ACE活性和AngⅡ水平则均比L组明显降低 (P <0 .0 5 )。结论 :辛伐他汀可能通过降低局部心肌组织ACE活性抑制NO缺乏性高血压大鼠心脏局部RAS活性 ,减少AngⅡ生成 。AIM: To investigate the effects of simvastatin on rennin angiotensin system in NO deficient hypertensive rats. METHODS: Twenty four male Wistar Kyoto rats were divided into three groups(n=8): Control (C) group, L NAME (L) group, L NAME plus simvastatin (L+S) group. Systolic blood pressure (SBP) was measured with tail cuff method every other week. After 8 week, the levels of TG , TC and AngII in plasma and the level of AngⅡ in myocardial tissue were also measured. The activity of ACE in serum and myocardial tissue were measured. RESULTS: L group demonstrated a persistent, time dependent elevation of SBP from baseline since second week. Simvastatin did not affect the blood pressure and the levels of TG, TC and AngⅡ in plasma among three groups. The activity of ACE in serum in L group was lower than C group (P< 0.01 ) . However, the activity of ACE and the levels of AngⅡ in myocardial tissue were higher than that of C group (P< 0.05 ). Simvastatin did not significantly increase the activity of ACE compared with L group (P> 0.05 ), but the activity of ACE and the concentrations of AngⅡ in myocardial tissue were significantly decreased in L+S group compared to L group (P< 0.05 ). CONCLUSION: Simvastatin may attenuate the activity of Local RAS in heart via reducing the activity of ACE and decreasing the production of AngⅡ.

关 键 词：肾素-血管紧张素系统 辛伐他汀 血管紧张素Ⅱ 高血压 实验动物 

分 类 号：R544.1[医药卫生—心血管疾病] R969.4[医药卫生—内科学]