我国藏族与维吾尔族健康志愿者异喹呱羟化代谢缺陷频率的研究  

STUDY ON THE FREQUENCY DISTRIBUTION OF DEBRISOQUINE HYDROXYLATION DEFICIENCY IN CHINESE HEALTHY ZANG AND WEI VOLUNTEERS

作　　者：匡唐泳 廖小曼 王克毅[2] 张远[1] 楼雅卿[1] 

机构地区：[1]北京医科大学药理教研室,北京100083 [2]西北民族学院药理组,兰州730030

出　　处：《药学学报》1991年第4期250-254,共5页Acta Pharmaceutica Sinica

摘　　要：本研究应用气相色谱法,测定了我国132位藏族和158位维吾尔族健康志愿者一次口服异喹胍(DB)10mg后8h尿中DB和4-羟异喹胍(4-OH-DB)的含量。结果表明,我国藏族和维族志愿者的DB羟化代谢均具双态性。求得藏及维族DB和4-OH-DB代谢比值的对数值(log MR)的范围分别为-0.70～1.54(MR为0.20～34.32)和-0.89～1.47(MR为0.13～29.73).以log MR=1.10为分界点,132位藏族和158位维族志愿者中分别有2个和1个弱代谢者。其缺陷频率分别为1.52和0.63%。吸烟和性别对DB羟化代谢的MR值无明显影响(P>0.2).服药后8h DB和4-OH-DB的回收率分别为:藏族19.83±10.99和10.81±6.58%;维族22.74±14.41和16.61±10.11%。The metabolic ratio of debrisoquine hydroxylation (MR) determined as the ratio of debrisoquine over 4-OH-debrisoquine in 8 h urine after a single oral dose of DB (10 mg) in unrelated Chinese Zang and Wei volunteers was studied by using gas chromatography. The MR of 132 healthy Chinese Zang subjects ranged from 0.20 to 34.32, and that of 158 healthy Chinese Wei subjects ranged from 0.13 to 29.73. Two phenotypes were apparent in the frequency distribution histograms with an antimode at log MR=1.10(MR=12.6). Two subjects were therefore identified as poor metabolizers (PMs)of DB in 132 Zang volunteers (the frequency of PMs was found to be 1.52%), and only one in 158 Wei volunteers (0.63%). Neither sex nor smoking habbit affected the DB hydroxylation (P>0.2). The recoveries of DB and 4-OH-DB in Zang volunteers were 19.83±10.99 and 11.57±7.04%, and in Wei volunteers they were 22.74±14.41 and 17.77±10.82%, respectively.

关 键 词：异喹胍 羟化代谢缺损 遗传多态性 

分 类 号：R968[医药卫生—药理学]