双氢青蒿素、磺胺多辛乙胺嘧啶联用治疗恶性疟的疗效观察  

Therapeutic effectiveness of dihydroartemisinin combined with sulfadoxine/pyrimethamine in patients with falciparum malaria.

作　　者：王善青[1] 蒙锋[1] 沈恒 闻岩 卓开仁[1] 朱其先[1] 庞学坚[1] 林世干[1] 曾林海[1] 

机构地区：[1]海南省热带病防治研究所,海口市570203 [2]北京市科泰新技术公司

出　　处：《中国热带医学》2002年第2期167-169,共3页China Tropical Medicine

摘　　要：目的　观察双氢青蒿素与磺胺多辛 乙胺嘧啶联合使用治疗恶性疟的疗效。　方法　以显微镜血检单纯恶性疟原虫阳性患者为观察对象 ,服药后按时测量体温和血检原虫 ,随访 2 8d ,观察治疗效果。结果　收治 36例恶性疟患者 ,全部治愈 ,无 1例复燃 ,治愈率为 10 0 %。平均退热时间为 ( 17.0± 9.9)h ,2 4h原虫下降率为 99.7%± 1.1%,原虫无性体转阴时间平均为 ( 2 6 .2± 9.4)h ,药后无明显不良反应。结论　双氢青蒿素与磺胺多辛 乙胺嘧啶联合使用治疗恶性疟具有良好的效果。Objective To observe the therapeutic efficacy of dihydroartemisinin combined with Sulfadoxine/Pyrimethamine in patients with falciparum malaria.Methods Patients with Plasmodium falciparum were selected as the subjects and were followed up in preselective time by blood and temperature examination for 28 days after they took the drugs.Result 36 patients with falciparum malaria were treated and followed up.All patients was cured and the cure rate in 28 days was 100%(36/39).The mean fever clearance time was(17.0±9.9)hours;the mean parasite clearance time was(26.2±9.4) hours;the mean rate of parasite reduce in 24 hours was 99.7%±1.1%.No apparent side-effect was observed.Conclusion Dihydroartemisinin combined with Sulfadoxine/Pyrimethamine is effective for the treatment of patients with falciprum malaria.

关 键 词：治疗 双氢青蒿素 磺胺多辛 乙胺嘧啶 恶性疟 疗效 

分 类 号：R531.3[医药卫生—内科学]