知母中一个新皂甙的分离和结构鉴定  

ISOLATION AND STRUCTURE DETERMINATION OF A NEW SAPONIN OF ANEMARRHENA ASPHODELOIDES

作　　者：郭冬[1] 李书[1] 池群[1] 孙文基 沙振方 赵效文 

机构地区：[1]陕西省中医药研究院,西安710003 [2]陕西省药品检验所,西安710061

出　　处：《药学学报》1991年第8期619-621,共3页Acta Pharmaceutica Sinica

摘　　要：知母(Anemarrhena asphodeloides Bge)具有清热除烦,泻肺滋阴等功能。已从中分离出多种皂甙,主要有知母皂甙(timosapognin)A1,A2,A3和B1,B2,其中以知母皂甙A3含量为最多。我们从陕西产知母用常规方法分离到两个化合物晶Ⅰ和晶Ⅱ(见图1)。晶Ⅰ为白色针晶,mp 174～6℃,[α]_D^(12)-3.9℃,高分辨质谱得出分子式为C_(27)H_(44)O_3。A new saponin, named smilageninoside, mp 265～ 7℃,was isolated from rhizomes of Anemarrhena asphdeloides by conventional method. The structure of smilageninoside was identified on the basis of IR, ~1HNMR, ^(13)CNMR and FAB-MS.Its structure was smilagenin 3 - O - [β- D- glucopyranosyl (1→ 2)] - β - Dmannopyranoside.

关 键 词：知母 新皂甙 皂甙 

分 类 号：R282.710.5[医药卫生—中药学]