犬冠状动脉内血浆包膜支架的生物相容性研究  

Biocompatibility of plasma coated stents in normal canine coronary arteries

作　　者：聂晓敏[1] 李庚山[1] 江洪[1] 吴钢[1] 朱中生[1] 王晓红[1] 杨新红[1] 漆曙辉[1] 

机构地区：[1]武汉大学人民医院心内科,湖北武汉430060

出　　处：《心脏杂志》2002年第3期184-186,共3页Chinese Heart Journal

基　　金：湖北省九五攻关项目冠心病的临床研究 ( No.96 2 p110 1)

摘　　要：目的 :评价血浆包膜支架在犬冠状动脉内的生物相容性。方法 :分别在犬左冠状动脉的回旋支和前降支随机植入 1个血浆包膜支架和 1个裸支架 ,术后 3d和 15 d(n=4)扫描电镜观察血小板粘附和血管内膜的内皮化情况 ,术后 1月 (n=5 )进行冠脉造影和光镜检查。结果 :支架植入术后 3d,血浆包膜支架组和裸支架组的血小板粘附数无显著差异 (P>0 .0 5 ) ;术后 15 d,两组血管内膜均完全被新生内皮细胞覆盖 ;术后 1月 ,两组血管的损伤程度相同 ,冠脉造影和病理学检查均显示 ,两组的狭窄程度无区别 ,血管壁无大量的异物巨细胞聚积。结论AIM:To evaluate the biocompatibility of plasma coated stents in normal canine coronary arteries.METHODS:Implation of plasma coated and non-coated stents was performed in the canine coronary arteries. The animals were killed after 3 d(n=4),15 d(n=4),1 month(n=5),and the vessels were harvested for scanning electron microscopy,histology,and morphometry.RESULTS:Stent thrombosis did not occur in either group and platelet adhesion were similar in both group at 3 d after stenting. At 15 d both the coated and non-coated stents were equally endothelialised. At 1 month there were no difference in intima thickness between the coated and non-coated stents and did not appear to elicit an adverse inflammatory response. CONCLUSION:In this animal model the plasma coating showed excellent blood and tissue compatibility.

关 键 词：血管成形术 气囊 支架 犬 冠状动脉内血浆包膜支架 生物相容性 

分 类 号：R318.1[医药卫生—生物医学工程]