新型促胃肠动力药物伊托必利  

Itopride hydrochloride,a new gastrointestinal prokinetic agent

作　　者：许大波[1] 柯美云[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院消化内科,北京100730

出　　处：《中国新药杂志》2002年第6期437-439,共3页Chinese Journal of New Drugs

摘　　要：伊托必利是一种具有阻断多巴胺D2 受体活性和抑制乙酰胆碱酯酶活性的促胃肠动力药物 ,其在中枢神经系统分布少 ,无致室性心律失常作用及其他严重药物不良反应和实验室异常。临床研究显示 。Itopride hydrochloride( itopride ) is a new gastrointestinal prokinetic agent.It regulated motility of the gastrointestinal tract through synergism of its dopamine D 2 receptor antagonistic action and its acetylcholine esterase inhibitory action.The concentrations of itopride in the brain were fairly low while it was distributed in the body.No evidence was found for its serious adverse reaction including its proarrhythmic effect.With data obtained from series of clinical study,it suggested that itopride could be a new choice of drug for treatment of gastroinestinal symptoms caused by reduced gastrointestinal motility in functional dyspepsia and chronic gastritis. [

关 键 词：促动力药 伊托必利 功能性消化不良 慢性胃炎 

分 类 号：R975[医药卫生—药品]