5种中药制剂杀灭幽门螺杆菌的实验研究  

Bactericidal action of 5 kinds of traditional herbal drugs for Helicobacter Pylori

作　　者：刘波[1] 李雪驼[1] 徐和利[1] 王海岩[1] 赵静玫[1] 孙艳[1] 杨晓明[2] 谷源平[2] 杨玉龙[2] 

机构地区：[1]中国科学院大连化学物理研究所生物技术部,大连116023 [2]大连市友谊医院,大连116011

出　　处：《中国新药杂志》2002年第6期457-459,共3页Chinese Journal of New Drugs

摘　　要：目的 :考察 5种中药制剂对幽门螺杆菌 (Hp)的杀菌作用。 方法 :采用平板涂布法 ,对黄连、枳实、紫草、逍遥汤、黄芪健中汤分别进行了Hp的杀菌试验 ,中药制剂处理浓度分别为 40 ,50和 55mg·mL-1 。结果 :在所选浓度范围内 ,5种中药制剂对Hp均有一定的杀灭作用 ;随着浓度的增加 ,杀菌作用增强。结论 :黄连、枳实和黄芪健中汤具有明显的杀菌作用 ,其中以黄连的杀菌效果较为显著 ,黄连处理浓度为 50mg·mL-1 时 ,杀菌率达 99.8%。Objective:To study the bactericidal action of 5 kinds of traditional herbal drugs for Helicobacter pylori (Hp).Methods:The 5 kinds of traditional herbal drugs,namely coptis chinensis ,the fruit of trifolite orange, Lithospermum erythrorhizo Sieb.et Zucc.and two decoctions of herb medicine,were tested for bactericidal action for Hp by the method of plate smearing with the concentration of 40,50 and 55mg·mL -1 ,separately.Results:In the scale of the selected concentration,the 5 kind of traditional herbal drugs had the bactericidal action for Hp,which became stronger with rise of its concentration.Conclusion:The coptis chinensis ,the fruit of trifolite orange and one decoction of herb medicine had notable effect,the coptis chinensis had most notable effect, the sterilizing rate was 99.8% with its concentration of 50mg·mL -1 . [

关 键 词：中药制剂 幽门螺杆菌 杀菌作用 实验研究 

分 类 号：R285.5[医药卫生—中药学]