缓释阿维菌素明胶微球的研制及其体外释放特性  

Studies on preparation and in vitro-release characteristics of a sustained-release avermectins-gelatin microspheres

作　　者：唐辉[1] 陈文[1] 姚新成[1] 洪成林[1] 陈坚[2] 

机构地区：[1]石河子大学药学院,石河子832002 [2]新疆医科大学药学院,乌鲁木齐830054

出　　处：《中国新药杂志》2002年第6期462-464,共3页Chinese Journal of New Drugs

基　　金：新疆维吾尔自治区科学与技术开发计划项目 ( 990 10 10 0 6 )

摘　　要：目的 :研究缓释阿维菌素明胶微球 (AVM GMS)的制备及其体外释放特性。方法 :采用乳化缩聚法以生物可降解材料明胶为囊材制备AVM GMS ,通过均匀实验设计法得到优化的处方和制备工艺。通过体外释药研究以累计释药百分率进行不同模型拟合 ,以说明AVM GMS的缓释作用。结果 :按优选处方和工艺制备的AVM GMS ,粒径在 1 0～ 2 0 0 μm之间 ,包封率为 68.6 %～ 74.1 %。体外释药规律符合Higuchi方程 ,AVM GMS的t1 2 是AVM原料药的 6 .6倍。结论 :AVM GMS具有明显的缓释作用。Objective:To prepare a sustained release avermectins gelatin microspheres(AVM GMS) and study its in vitro release characteristics.Methods:AVM GMS was prepared from the biodegradable gelatin by emulsion polymerization,and the optimum formulation and preparation technical process was afforded by the uniform test.The release profile of AVM GMS was shown from the accumulative drug release amount in vitro .Results:The experiment conditions were optimized, the mean volume diameter obtained was 10～200μm and encapsulation rate was 68.6%～74.1%.The profile could be described by Higuchi equation.The release t 1/2 of AVM GMS was about 6.6 times as much as that of original AVM.Conclusion:AVM GMS had obviously sustained effect. [

关 键 词：阿维菌素 明胶微球 缓释剂 体外释药 

分 类 号：R978.6[医药卫生—药品] R944.9[医药卫生—药学]