各型肝病患者血浆内皮素的初步研究  

Primary Study on Plasm Endothelins of Patients with Different Types of Liver Diseases

作　　者：褚瑞海[1] 玄恩余[1] 梁秀玲[1] 王洪刚[1] 

机构地区：[1]潍坊医学院附属潍坊市人民医院传染科,山东潍坊261041

出　　处：《潍坊医学院学报》2002年第1期26-28,共3页Acta Academiae Medicinae Weifang

基　　金：潍坊市科委资助课题 (课题号 :1 998 2 6)

摘　　要：目的　探讨ET与各型肝病的关系。方法　用放射免疫分析法测定 14 4例急性、慢性肝炎、肝硬化腹水患者血浆的ET浓度 ,并进行横向比较。结果　急性肝炎组及慢性肝炎组ET水平均较正常组显著升高 (P <0 .0 5 ) ,而肝硬化腹水组 ,较正常对照组显著降低 (P <0 .0 5 ) ,肝硬化腹水组 ,与急性肝炎组及慢性肝炎组ET水平比较 ,差异非常显著 (P <0 .0 1)。急性肝炎组患者血清ALT、血浆ET水平呈显著正相关 (P <0 .0 5 ) ;肝硬化腹水组患者血浆ET与血清钠及血浆白蛋白呈显著正相关 (P <0 .0 5 )。结论　①急性肝炎、慢性肝炎患者血浆ET水平显著升高 ;②肝硬化腹水组血浆ET水平均显著降低 ;③ET在急性肝炎、慢性肝炎、肝硬化腹水发病中起着重要作用。Objective To reveal the relationship of ETs and different types of liver diseases.Methods The levels of ETs of 144 different liver diseases was measured by radioimmunoassay with immuno counter and a cross comparision were carried on.Result The plasm level of ET in acute and chronic group were higher significantly than in control group(P<0.05),while the cirrhosis with ascites group(including with SBP and without SBP) were lower significantly than control group(P<0.05);The levels of ET in acute and chronic group were higher significantly than cirrhosis with ascites group(P<0.01).Line relative analysis showed that ALT were positively relative with ET in acute hepatitis group(P<0.05),ETs were positively relative with Na + and album in cirrhosis with ascites group(P<0.05).Conclusion ①The plasm level of ET in acute and chronic group was increased significantly;②The plasm level of ET in cirrhosis with ascites group(including with and without SBP) was decreased significantly;③ET palyed an important role in the development of acute,chronic,cirrhosis with ascites.

关 键 词：肝炎 急性 肝炎 慢性 肝硬化腹水 内皮素 

分 类 号：R512.62[医药卫生—内科学]