桃仁不同提取物抗血栓作用的实验研究  

Experimental Study on Anti-thrombus Effect of Different Extracts from Semen Persicae

作　　者：汪宁[1] 刘青云[1] 彭代银[1] 王兰[1] 王胜祥[1] 

机构地区：[1]安徽中医学院药学系,合肥230038

出　　处：《中药材》2002年第6期414-415,共2页Journal of Chinese Medicinal Materials

摘　　要：目的:比较桃仁不同提取物抗血栓作用,为寻找确定其抗血栓作用有效部位提供实验依据。方法:制备桃仁不同提取物,观察其对小鼠凝血时间、ADP诱导的小鼠肺血栓状态及电刺激大鼠颈总动脉血栓形成的影响。结果:桃仁的乙酸乙酯提取物能延长小鼠的凝血时间、缓解ADP诱导的小鼠肺栓塞所致的呼吸窘迫症状,能明显延长实验性大鼠血栓形成的时间。结论:桃仁乙酸乙酯的提取物有显著的抗血栓作用。Objective: To observe the effects of anti-thrombus of different extracts from Semen Persicae and provide experimental basis for finding and defining effective fraction of Semen Persicae. Methods:The effects of different extracts from Semen Persicae on clotting time in mice, pulmonary embolism in mice and electro-irritate thrombosis in rats were observed. Result:Ethyl acetate extract fron Semen Persicae could prolong clotting time in mice, markedly relieve respiratory difficult due to pulmonary embolism in mice induced by ADP-Na, obviously retard the generation of thrombosis induced by electrical injury of carotid artery in rats. Conclusion: Ethyl acetate extract from Semen Persicae possesses evidently anti-thrombotic effect.

关 键 词：桃仁 提取物 乙酸乙酯 抗血栓作用 实验研究 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]