常通口服液对实验性肠粘连兔纤溶活性的影响  

Effect of Changtong Oral Liquids on the Fibrinolytic Activity of Rabbits with Experimental Intestinal Adhension

作　　者：李霄[1] 侯连兵[1] 单有亮[1] 佟丽[2] 陈育尧[2] 

机构地区：[1]第一军医大学南方医院药学部,广州510515 [2]第一军医大学中医系,广州510515

出　　处：《中药材》2002年第6期416-417,共2页Journal of Chinese Medicinal Materials

基　　金：国家重点科技攻关项目(96-901-05-245)

摘　　要：目的:观察常通口服液(CTOL)对实验性肠粘连兔纤溶活性的影响。方法:仿 Thomas and Rhoads方法制作兔肠粘连模型,并以CTOL连续预防给药灌服7天后,兔耳静脉采血检测t-PA和PAI活性的变化,并肉眼观察兔肠粘连的情况。结果:CTOL各剂量组对兔术后肠粘连有明显的预防作用,并使其血中t-PA活性增高,PAI显著下降。结论:CTOL可能是通过调节机体的纤溶系统以达到防治术后肠粘连的作用。Objective: To observe the effect of Changtong Oral Liquid ( CTOL) on the fibrinolytic activity of rabbits with experimental intestinal adhension. Methods: Intestinal adhension model of rabbits were made with reference to that described by Thomas and Rhoads and the animals were continuously orally supplemented with CTOL for seven days. Changes of tissue plasminogen activator (t-pA) and plasminogen activator inhibitor activity (PAI) as well as the intestinal adhension were investigated. Results: Different dosage of CTOL produced protective effects on the postoperative intestinal adhension accompanied by significant enhancement of t-PA activity and pronounced decreasement of PAI activity.Conclusion: CTOL maybe play protective role in postoperative intestinal adhension by modulating the activity of fibrinolytic system.

关 键 词：常通口服液 组织纤溶酶原激活剂 纤溶酶原激活剂抑制因子 肠粘连 

分 类 号：R285.5[医药卫生—中药学]