超排卵时卵巢对促性腺激素的反应与颗粒细胞促卵泡激素受体的表达  被引量:13

Follicle-stimulating hormone receptor levels in relation to ovarian cycling response from gonadotropin hormone stimulation

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作  者:楼航英[1] 黄荷凤[1] 金帆[1] 

机构地区:[1]浙江大学医学院附属妇产科医院,浙江杭州310006

出  处:《浙江大学学报(医学版)》2002年第3期151-154,共4页Journal of Zhejiang University(Medical Sciences)

基  金:浙江省自然科学基金 (30 0 4 6 7)

摘  要:目的 :探讨促排卵周期卵巢对促性腺激素反应性与颗粒细胞促卵泡激素受体 (FSHR)表达的关系。方法 :根据取卵时卵泡发育数不同 ,将卵巢对促排卵药物的反应分为低反应型 (卵泡数≤ 3个 )、中反应型 (卵泡数 4~13个 )和高反应型 (卵泡数≥ 14个 ) ,分别为 11例、15例和 13例。采用逆转录聚合酶链反应 (RT- PCR)测定 3种反应类型的卵泡颗粒细胞 FSHR m RNA的表达量。结果 :低反应型 FSHR m RNA表达量显著低于中、高反应型 (相对积分值分别为 0 .5 4± 0 .0 7、0 .90± 0 .17和 1.2 0± 0 .4 5 ,P<0 .0 5 )。结论 :卵巢对促性腺激素的反应与颗粒细胞FSHR m RNA的表达量高低有关。Objective: To investigate the relationship between the ovarian response,induced by gonadotropin hormone, and levels of follicle stimulating hormone receptor (FSHR). Methods:The level of ovarian response was divided into three groups based on the number of follicles obtained during oocyte retrieval: poor responders (<4 follicles), normal responders (4~13) and high responders (>13 follicles). FSHR mRNA was measured using reverse transcription polymerase chain reaction (RT PCR). Results: The expression of FSHR mRNA in the poor responders was 0.54±0.07. This was much lower than that of the normal responders who were at 0.90±0.17, and the high responders who were at 1.20±0.45( P <0.05). Conclusion: Ovarian response induced by gonadotropin hormone stimulation is correlated with the level of FSHR mRNA in the granulosa cells.

关 键 词:超排卵 卵巢 促性腺激素 颗粒细胞 促卵泡激素受体 

分 类 号:R711.6[医药卫生—妇产科学]

 

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