白细胞介素-2及其受体与胰岛移植排斥反应发生的相关性及其意义  

The detection of serum IL-2 and SIL-2R and its significance in islet xenograft rejection

作　　者：申哲洙[1] 王有德[1] 吴后男[2] 张学春[1] 

机构地区：[1]吉林大学第一医院普外科,长春130021 [2]吉林大学基础医学院病理学教研室

出　　处：《中华实验外科杂志》2002年第4期304-305,共2页Chinese Journal of Experimental Surgery

摘　　要：目的　探讨检测血清中白细胞介素 2 (IL 2 )及其受体 (SIL 2R)的含量对异种胰岛移植排斥反应中的意义。方法　昆明小鼠为供体 ,Wistar大鼠为受体。分 4组 :A组为糖尿病对照组 ,B组为单纯胰岛移植组 ,C组为胰岛和胸腺联合移植组 ,D组为胸腺细胞胸腺内预注射后 ,胰岛和胸腺联合移植组。移植后用酶联免疫吸附试验 (ELISA法 )检测IL 2、SIL 2R含量。结果　血清中IL 2在胰岛排斥前 4d开始有显著升高 (P <0 .0 0 1) ,而SIL 2R在排斥前 3d开始显著升高 (P<0 .0 0 1)。两者含量一直升高至排斥当日。结论　检测IL 2、SIL 2R含量在异种胰岛移植是否发生排斥反应具有重要意义。Objective To study the significance of serum IL 2 and IL 2R detection in islet xenograft rejection.Methods Kunming mice were used as donors and Wistar rats as recipients.Group A was diabetic rats as control.Group B received islet xenotransplantation only.Combined islet and thymus xenotransplantation was performed in group C.Donor thymus cells were injected into recipients thymus.combined islet and thymus xenotransplantation was performed in group D.Serum IL 2 and IL 2R were detected by using ELISA after transplantation.Results Serum IL 2 was increased significantly (P< 0.001) 4 days before islet xenograft was rejected,while serum ILP<0.001) 3 days before rejection.Both of them didnt stop increasing until day of rejection.Conclusion The detection of IL 2 and IL2R is effective to predict the occurrence of islet xenograft rejection.

关 键 词：白细胞介素-2 胰岛移植 相关性 白细胞介素-2受体 排斥反应 

分 类 号：R657.5[医药卫生—外科学]