腺苷对家兔心脏房室结区不同细胞的动作电位的影响  

The Effect of Adenosine to the Action Potential in the Different Region of Rabbit Heart AV Node

作　　者：姚素波[1] 孙强[2] 杨庆[3] 贺勇[3] 胡宏德[3] 崔凯军[3] 黄德嘉[3] 

机构地区：[1]四川大学华西医院金卡医院,四川成都610041 [2]四川大学华西医院药剂科,四川成都610041 [3]四川大学华西医院心内科,四川成都610041

出　　处：《华西医学》2002年第2期199-200,共2页West China Medical Journal

摘　　要：为探讨房室交界区各部位的电生理特性以及腺苷对各部位的动作电位特性的影响 ,本文对 2 0只家兔制作了房室结立体标本 ,用标准微电极技术法记录了不同部位房结区 (AN)、结区 (N)、结希区 (NH)以及冠状窦口周围和三尖瓣 ,二尖瓣房室环上的动作电位形态及腺苷对其的影响。结果表明似房结区 ,似结区及似结希区的动作电位图形分布广泛 ,除在传统的房室结可记录到此组动作电位图形外 ,在冠状窦及房室环周围也可记录到类似图形。腺苷对各区细胞的作用也明显不同 ,其共同的作用为缩短动作电位时程 ,减慢心率。结果提示房室交界区或称为广义的房室结是一结构和功能复杂的结合体 ,对其结构和功能结合起来研究才能真正了解其电生理特性。The aims of study the electrophysiological on the junction of AVN and effect of adenosine in isolated AV node preparation(n=20),By means of microelectrode techniques,the electrophysiological feature and effects of adenosine were investigated on atrionodal(AN)?node(N)?nodal His(NH)cells in the AVN area of rabbit heart and around coronary sinus(CS)and the tricuspid annulus(TV).The results showed that the like AN?like N?like NH action potential were found in CS and TV beside tranditional regions of AVN.Effects of adenosine are defferent in the defferent regions of AV node.Adenosine decrease the duration and amplitude of the action potential of atrionodal?node cells and depressed the maxium rate of rise of the action potential of nodal cells.The results showed that the juntional AV node means is a complex mass with different constracture and function.

关 键 词：腺苷 家兔 心脏房室结区 动作电位 影响 房室结折返性心动过速 

分 类 号：R541.7[医药卫生—心血管疾病]