单个活细胞膜驰豫时间的动态光散射测量  

Dynamic Light Scattering Measurement of Single Living Cell Membrane Relaxation Time

作　　者：王江成[1] 唐光辉[1] 刘永军[1] 

机构地区：[1]石河子大学师范学院物理系,新疆石河子832003

出　　处：《中国血液流变学杂志》2002年第2期88-90,共3页Chinese Journal of Hemorheology

基　　金：石河子大学中青年学术科研基金赞助

摘　　要：对单个活体红细胞、小鼠皮层神经元细胞进行了动态光散射测量。较新生红细胞膜的散射光驰豫时间比老红细胞短。小鼠皮层神经元细胞膜散射光驰豫时间在加入 β/A4淀粉样蛋白后延长。提示随红细胞日龄的增加 ,红细胞膜的流动变形能力下降 ;β/A4淀粉样蛋白降低皮层神经元细胞膜的流动性 ;表明本技术适用于单个活体细胞膜动态研究。Single living red cell & cortex cell of mice were studied using dynamic light scattering. The results shows, scattering light relaxation times of young red cell membranes are shorter than those of old red cell membranes; relaxation times of scattered light from cortex cell membranes of mice become longer after adding β/A4 amyloid peptide.This indicates, fluidity and deformability of red cell membrane decreases during aging;β/A4 amyloid peptide reduces fluidity of cortex cell membrane of mice. It shows that the technique proposed is feasible and suitable for single living cell membrane dynamic study.

关 键 词：单个活细胞 膜 动态光散射 驰豫时间 红细胞 

分 类 号：R331.141[医药卫生—人体生理学] Q632[医药卫生—基础医学]