氢溴酸加兰他敏的透皮吸收  

Transdermal absorption of galanthamine hydrobromide through mice skin in vitro

作　　者：徐子猷[1] 黄赛杰[2] 阮连军 

机构地区：[1]复旦大学药学院物理化学教研室,上海200032 [2]上海第二医科大学附属仁济医院药剂科,上海200001 [3]金山中心医院药剂科,上海201500

出　　处：《药学服务与研究》2002年第2期88-91,共4页Pharmaceutical Care and Research

摘　　要：目的:探讨氢溴酸加兰他敏的透皮吸收特性。方法:用紫外双波长分光光度法检测浓度,采用V～C水平扩散地.比较氢溴酸加兰他敏在不同pH条件下的渗透系数,同时研究几种常用促透剂对氢溴酸加兰他敏渗透系数的影响。结果:在pH=8的条件下,氢溴酸加兰他敏的渗透系数增大。1％月桂氮(?)酮和1％月桂氮(?)酮+10％丙二醇可显著增大氢溴酸加兰他敏的渗透系数。结论:氢溴酸加兰他敏的透皮吸收受促透剂、介质pH等理化性质的影响。Abjective: To observe the transdermal absorption characteristics of galanthamine hydrobromide. Methods: Double wavelength ultraviolet spectrophotometry and V-C horizontal diffusion cell were used to compare the permeability coefficient of galanthamine hydrobromide in media with different pH and the effect of several penetration enhancers. Results: The permeability coefficient of galanthamine hydrobromide rose at pH = 8 when compared with pH = 5. 4. One percent azone and 1% azone +10% propylene glycol could obviously enhance the permeability coefficient of galanthamine hydrobromide. Conclusion: The transdermal absorption of galanthamine hydrobromide is influenced by the penetration enhancers and the pH of media.

关 键 词：氢溴酸加兰他敏 皮肤吸收 渗透系数 

分 类 号：R971.9[医药卫生—药品]