钾防治血管成形术后再狭窄的临床研究  

Potassium in prevention of restenosis after PTCA

作　　者：谭宁[1] 周颖玲[1] 陈纪言[1] 罗建方 李瑜辉[1] 陈泗林[1] 张春祥[1] 唐其东[1] 冯建章[1] 

机构地区：[1]广东省心血管病研究所心内科,广州市510100

出　　处：《岭南心血管病杂志》2002年第3期178-182,共5页South China Journal of Cardiovascular Diseases

摘　　要：目的　观察钾在临床上预防PTCA术后再狭窄的安全性和有效性。方法　 80例PTCA患者随机分为对照组 (40例 )用常规治疗 ;治疗组 (40例 )常规治疗加钾缓释片 (Slow K) 1 2g ,q8h ,于术前 3d开始服药至术后 6个月。将两组的多项观察指标进行比较分析。结果　 77例完成随访 ,治疗组平均能提高血钾浓度 0 3mmol/L ,血Na+ 、Cl-、Ca2 + 、Mg2 + 水平两组间无显著性差异 ;可疑心绞痛和心肌缺血于对照组有 14例 (2 8 9% ) ,而治疗组仅有 7例 (17 9% ) ;冠脉造影随访对照组 2 1例中有 11例出现再狭窄 ,而治疗组17例中有 6例 ;随访期间对照组有 2 3 7% ;治疗组有 10 2 %需再次行血管重建术 (包括PTCA和CABG ) ,但两组比较P =0 116。结论　钾剂治疗初步显示 :PTCA术后心肌缺血再发率、冠脉造影再狭窄例数以及因再狭窄需要再次行血管重建术例数 。Objectives To investigate safety and effectivity of potassium in prevention of restenosis after PTCA. Methods Eighty patients with PTCA were randomized into two groups:Control group (Group Ⅱ n= 40) with conventional therapy;Treatment group(Group Ⅰ n= 40) with conventional therapy plus oral potassium (Solw K 1 2 g,q8h,given 3 days before PTCA and continued to the end of sub study). Observation indeces of two groups were compared in follow up Results Seventy seven patients were followed up (39 in group I,38 in group Ⅱ) All blood indices (including fat,sugar,uric acid,cretonne,Na +,Cl -,Ca 2+ ,Mg 2+ ) except blood potassium in both groups were similar Oral potassium could increase blood potassium level about 0 3 mmol/L in group Ⅰ without causing any side effects Suspicious angina pectoris and evidence of myocardial ischemia by ETT developed in group Ⅱ had 14 patients (28 9%) and Group Ⅰ had 7 patients(17 9%); restenosis confirmed by coronary arteriography appeared. 10 2% in group Ⅰ (4/39) and 23 7% in group Ⅱ (9/38) needed revascularizations (PTCA or CABG) Conclusion Therapy with potassium after PTCA showed that recurrence of myocardial ischemia,restenosis rate by follow up coronary arteriography and revascularization rate tended to be lower in group Ⅰ than group Ⅱ

关 键 词：钾 血管成形术 再狭窄 冠心病 冠脉造影 经皮冠脉腔内成形术 

分 类 号：R654.206[医药卫生—外科学]