人参制剂中人参皂甙在大鼠小肠中的吸收(英文)  

Absorption of Ginsenosides of Ginseng Preparations in Rat Small Intestine

作　　者：赵浩如 李振泉~~ 

出　　处：《中国药科大学学报》2002年第3期191-191,共1页Journal of China Pharmaceutical University

摘　　要：AIM Since bioavailability of ginsenosides is small by oral administration,the absorption of ginsenosides in the small intestine was studied.METHODS The absorption action was investigated in an in situ perfusion model of rat small intestine.A ginseng(root of Panax ginseng C. A. Meyer) decoction and a ginsenosides liquor was used as perfusion solution. RESULT AND CONCLUSION A mean value for ginsenosides absorbed in 3 hours per rat was 21.79 mg and 18.41 mg,respectively.Absorption of ginsenosides in the ginsenosides liquor basically followed first-order reaction of kinetics.The absorption of ginsenosides in the decoction was delayed in the second hour.The results confirm that the small intestine has normal ability to absorb ginsenosides.It is suggested that the prepartions containing ginsenosides should be protected from acid hydrolysis in stomach and absorbed as completely as possible in small intestine.AIM Since bioavailability of ginsenosides is small by oral administration,the absorption of ginsenosides in the small intestine was studied.METHODS The absorption action was investigated in an in situ perfusion model of rat small intestine.A ginseng(root of Panax ginseng C. A. Meyer) decoction and a ginsenosides liquor was used as perfusion solution. RESULT AND CONCLUSION A mean value for ginsenosides absorbed in 3 hours per rat was 21.79 mg and 18.41 mg,respectively.Absorption of ginsenosides in the ginsenosides liquor basically followed first-order reaction of kinetics.The absorption of ginsenosides in the decoction was delayed in the second hour.The results confirm that the small intestine has normal ability to absorb ginsenosides.It is suggested that the prepartions containing ginsenosides should be protected from acid hydrolysis in stomach and absorbed as completely as possible in small intestine.

关 键 词：人参皂甙 人参 吸收 

分 类 号：R285.5[医药卫生—中药学]