盐酸维拉帕米自乳化缓释片的研制及释药行为的探讨  

Development of Verapamil Hydrochloride Self-Emulsifying Sustained-Release Tablets and Exploration of Released Character

作　　者：张瑛[1] 张钧寿[1] 陈国广[1] 张芳[1] 王猛[1] 

机构地区：[1]中国药科大学药剂学教研室,南京210009

出　　处：《中国药科大学学报》2002年第3期208-210,共3页Journal of China Pharmaceutical University

摘　　要：目的　探索固体自乳化释药系统 ,研制自乳化缓释片 ,考察体外释药行为。方法　以盐酸维拉帕米 (VerapamilHydrochloride ,VH)为模型药物 ,以吐温 80 (Tween80 ) ,豆磷脂 (sbpc)为乳化剂 ,以羟丙甲纤维素(HPMC) ,卡波普 (carbopol)为骨架材料 ,制备自乳化缓释片。结果　以含吐温 80和豆磷脂 10 % ,羟丙甲纤维素和卡波普 30 %的处方乳化效果好 ,体外释药符合要求。结论　通过调节乳化剂和骨架材料的比例 。AIM Self emulsifying drug delivery systems were studied. Verapamil Hydrochloride self emulsifying sustained release tablets were developed and evaluated \%in vitro\% release characteristics. METHODS The Verapamil Hydrochloride formulations were screened according to the designed \%in vitro\% release rate by the use of Tween80, Sbpc as emulsifier and HPMC, and carbopol as the gel matrix. RESULTS The self emulsifying sustained release tablets prepared containing 10% emulsifier and 30% gel matrix were preferable. CONCLUSION Adjusting the ingredients of formulation may obtain the desirable self emulsifying sustained release tablets.

关 键 词：自乳化药物传递系统 缓释片 盐酸维拉帕米 

分 类 号：R943[医药卫生—药剂学]