HLA-DR抗原在斑秃皮损中的表达  

Study on the expression of HLA-DR antigens in alopecia areata lesions

作　　者：李美洲[1] 高顺强[1] 张学新[1] 丁政云[1] 梁祖琪[1] 

机构地区：[1]河北医科大学第四医院皮肤科,050011

出　　处：《中国麻风皮肤病杂志》2002年第2期118-119,共2页China Journal of Leprosy and Skin Diseases

摘　　要：目的 :　探讨斑秃的发病机理。方法 :　应用免疫组化的方法 (SP法 )观察了HLA -DR抗原在 15例斑秃皮损中及 8例正常头皮组织中的表达情况。结果 :　HLA -DR抗原在斑秃皮损毛囊角质形成细胞中明显表达 ,占 6 0 %(9 15 ) (P <0 .0 5 ) ;HLA -DR抗原在正常头皮中未见表达。结论 :　HLA-DR抗原参与了斑秃发病 ,免疫功能紊乱可能是斑秃的发病因素。Objectives:Objective: To investigate the pathogenesis of alopecia areata (AA).Method:Immunohistochemical technology (SP method) was used to detect the HLA-DR antigens in scalp specimens from15 cases of AA and 8 normal controls. Results: HLA-DR antigens were obviously expressed on follicular keratinocytes in AA lesions (9/15), but not in normal scalp skin (P<0.05) Conclusion: HLA-DR antigens play a role in AA, and immune dysfunction may be a possible mechanism that results in the development of AA.

关 键 词：表达 斑秃 HLA-DR抗原 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]