PASI临床指标可靠性评价  

Assessment on the reliability of component of PASI

作　　者：张长宋[1] 陈树民[1] 

机构地区：[1]山东省皮肤病性病防治研究所,250022

出　　处：《中国麻风皮肤病杂志》2002年第2期120-121,共2页China Journal of Leprosy and Skin Diseases

摘　　要：目的 :　评价银屑病PASI记分系统中红斑、脱屑、浸润和受累面积指标的可靠性。方法 :　按PASI记分法 ,三位皮肤科医生分别对银屑病患者进行评估 ,将所得资料计算各指标的Kappa值。结果 :临床症状指标的红斑、脱屑和浸润Kappa值分别为 0 .36 1、0 .384、0 .319,均 <0 .4,一致性较差。受累面积指标Kappa值为 0 .5 92 ,一致性不满意。结论 :　应用PASI法评价寻常型银屑病病情严重性的可靠性较差 ,在应用PASI做为评价工具的临床药物试验中对结果解释应慎重。Objective: To assess the reliability of each component of psoriasis severity and area index (PASI) i.e., erythema, desquemation, infiltration and body area (BSA)in patients with psoriasis vulgaris. Method:The scores of PASI and its components in patients with psoriasis vulgaris were obtained by three dermatologists independently, and then, Kappa value of each component was calculated.Results: low agreements were found among the three clinical components (Kappa values of erythema, desquamation and infiltration, were 0.361, 0.384 and 0.319, respectively). Modest agreement was reached with BSA with a Kappa value of 0.592. Conclusion: Reliability of PASI is not satisfing in this study setting and the study result of a clinical trial using PASI as evaluation tool should be explained cautiously.

关 键 词：PASI 评价 银屑病 可靠性 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]