^(99)Tc^m-MDP骨显像评价异体骨移植的价值  

Value of ~99Tc^m-MDP Bone Imaging in Evaluating Bone Allograft Transplantation

作　　者：陈庆[1] 顾洁夫[1] 蔡林[1] 汪长银[2] 文兵[2] 汪鹏[1] 

机构地区：[1]武汉大学中南医院骨科,湖北武汉430071 [2]武汉大学中南医院核医学科,湖北武汉430071

出　　处：《中国医学影像技术》2002年第6期506-508,共3页Chinese Journal of Medical Imaging Technology

基　　金：湖北省科委科研基金资助项目 (972 91 2 )

摘　　要：目的　研究99Tcm MDP骨显像评价异体骨移植的意义。方法　于 18只新西兰大白兔两侧桡骨干处造成 15mm缺损 ,随机分为A、B两组 ,A组植入碱性成纤维细胞生长因子 (bFGF)与异体冻干骨的复合物 ,B组单纯植入冻干骨。于术后 2 ,4,6周行放射性核素骨显像、组织学切片和X线检查。并另选 3只大白兔作为正常对照。结果　①未出现并发症的移植骨均存活 ,它们的放射性浓度在术后 2周增加 ,4周达高峰 ,以后逐渐下降 ,其动态变化与组织形态学改变一致并早于X线改变。②A组的放射性浓度始终高于B组。③另有 2例术后感染 ,在 2周时放射性浓度下降 ,经治疗后 ,恢复正常。Objective To study the value of 99 Tc m MDP bone imaging in evaluating the bone allograft transplantation. Methods The 15mm segmental bone/periosteum defects were created on bilateral radius in 18 New Zealand rabbits and were treated with two different kinds of implants: A, freeze dried bone allograft combined with basic fibroblast growth factor (bFGF);B, freeze dried bone only. The repairs of defects were observed radiologically and histologically and was analyzed by radionuclide bone imaging.Other 3 rabbits were chosen as normal control. Results ①All the bone allografts without complications were survived.Their radioactivities increased at the 2nd week, reached the summit at the 4th week, and then decreased gradually.The changes of radioactivity were consistent with that of histology,and were earlier than those of X ray examination. ② The radioactivities of group A were higher than those of group B. ③ Other 2 cases were infected after operation, the radioactivity dropped at the 2nd week. They recovered normally after treatment at the 4th week. Conclusion Radionuclide bone imaging can assess the survival of bone allograft and evaluate the osteogenic activity of implantation.

关 键 词：放射性核素骨显像 骨移植 锝99-MDP 

分 类 号：R687.34[医药卫生—骨科学] R817.4[医药卫生—外科学]